| Type | Description |
|---|---|
| Definition | sodium channel, voltage-gated, type III, alpha |
| Date | Results | Publications |
|---|---|---|
| 2019-08-24 12:14:00 | Nav1.3 is expressed in neutrophils in vivo and regulates attachment, transmigration, and chemotaxis. | 29509584 |
| 2019-07-06 11:11:00 | enterochromaffin (EC) cells use Scn3a-encoded voltage-gated sodium channel NaV1.3 for electrical excitability and 5-HT release. NaV1.3-dependent electrical excitability and its contribution to 5-HT release is a novel mechanism of EC cell function | 29142310 |
| 2018-02-24 11:44:00 | Novel de novo variant SCN3A-L247P was demonstrated to cause a defect in trafficking, which would be predicted to functionally reduce SCN3A activity. Consistent with the clinical observations, Scn3a+/Hyp mice display increased seizure susceptibility, hypoactivity, and impaired motor learning. | 28235671 |
| 2017-12-23 12:15:00 | Scn3a was mapped to the QTL for febrile seizure susceptibility. | 27690330 |
| 2016-03-12 11:08:00 | a huge difference in electrophysiological function between SCN1A and SCN3A mutations in the pore region; this might explain the more common SCN1A mutations detected in patients with epilepsy and the more severe phenotypes associated with these mutations | 24990319 |
| Type | IDs |
|---|---|
| Synonymous | Gm1000, Nav1.3 |
| Gene |
UniProtKB-ID:
SCN3A_MOUSE,
Q3UF73_MOUSE
UniprotKB:
A2ASI5,
Q3UF73
UniParc:
UPI0000D777E6,
UPI0005AB95ED,
UPI00071EF7BA,
UPI00005AC82A
EMBL:
AK148881,
AL772235,
KM373690,
AL928621,
KM373689
Ensembl:
ENSMUSG00000057182
KO:
mmu:20269
|
| Nucleutide sequences |
EMBL-CDS:
AIW80042.1,
AIW80041.1,
BAE28688.1
Ensembl_TRS:
ENSMUST00000066432,
ENSMUST00000100069
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000065023,
ENSMUSP00000097647
RefSeq:
XP_006499094.1,
NP_001342098.1,
NP_001342097.1,
NP_001342100.1,
NP_001342095.1,
NP_061202.3,
NP_001342096.1,
NP_001342099.1,
XP_011237693.1
|
| Others |
UniRef100:
UniRef100_A2ASI5,
UniRef100_Q3UF73
UniRef90:
UniRef90_Q3UF73,
UniRef90_Q9NY46
UniRef50:
UniRef50_Q9NY46
UniGene:
Mm.330256
CCDS:
CCDS50596.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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