| Type | Description |
|---|---|
| Definition | sodium channel, voltage-gated, type X, alpha |
| Date | Results | Publications |
|---|---|---|
| 2021-03-20 13:27:00 | Aberrant subchondral osteoblastic metabolism modifies NaV1.8 for osteoarthritis. | 32441256 |
| 2020-01-04 10:40:00 | 2 disease mutations (T790A and G1663S) in Nav1.8 that induce nociceptor hyperexcitability increase resurgent currents in DRG neurons which greatly prolong action potential duration and enhance repetitive firing. The transfected G1663S mutation doubled resurgent currents in rat DRGs, and the transfected T790A mutation increased them fourfold. Nav1.8 open-channel block is a major factor in Nav1.8-associated pain mechanisms. | 30617209 |
| 2019-11-02 10:24:00 | required in all heat-resistant nociceptors to encode temperatures higher than approximately 46 degrees C | 29970412 |
| 2019-05-11 11:04:00 | We find that approximately 80% of neurons responsive to cold down to 1 degrees C do not express NaV1.8, and that the genetic deletion of NaV1.8 does not affect the relative number, distribution, or maximal response of cold-sensitive neurons. Furthermore, the deletion of NaV1.8 had no observable effect on transient cold-induced (>/=5 degrees C) behaviors in mice, as measured by the cold-plantar, cold-plate (5 and 10 deg... | 30755524 |
| 2018-07-28 10:21:00 | Nav1.8 role in the inflammatory pain.CXCL13, upregulated by peripheral inflammation, acts on CXCR5 on dorsal root ganglia neurons and activates p38, which increases Nav1.8 current density and further contributes to the maintenance of inflammatory pain. | 27708397 |
| Type | IDs |
|---|---|
| Synonymous | Nav1.8, PN3, SNS |
| Gene |
UniProtKB-ID:
SCNAA_MOUSE,
K3W4P8_MOUSE
UniprotKB:
Q6QIY3,
K3W4P8
UniParc:
UPI0000242074,
UPI0000498088,
UPI00000E8677,
UPI0000D8B320
EMBL:
AJ623269,
AJ622906,
L42342,
AC171201,
AJ623270,
AY538273
Ensembl:
ENSMUSG00000034533
KO:
mmu:20264
|
| Nucleutide sequences |
EMBL-CDS:
AAA68000.1,
AAS45602.1,
CAF25040.1,
CAF22039.1,
CAF25039.1
Ensembl_TRS:
ENSMUST00000213392,
ENSMUST00000084787,
ENSMUST00000214408
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000148987,
ENSMUSP00000081845,
ENSMUSP00000150830
RefSeq:
NP_033160.2,
XP_017168711.1,
XP_017168710.1,
NP_001192250.1,
XP_017168712.1,
XP_036010631.1
|
| Others |
UniRef100:
UniRef100_Q6QIY3,
UniRef100_K3W4P8
UniRef90:
UniRef90_Q62968
UniRef50:
UniRef50_Q9Y5Y9
UniGene:
Mm.247042
CCDS:
CCDS90682.1,
CCDS57716.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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