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201254 CENPX

201254

CENPX

centromere protein X

protein-coding

Homo sapiens

基因描述

Type Description
Definition centromere protein X

研究结论

Date Results Publications
2015-10-31 11:32:00 MHF prefers branched DNA over dsDNA because it engages two duplex arms. MHF engages DNA forks or various four-way junctions independent of the junction-site structure. The DNA-binding interface of MHF is important for cellular resistance to DNA damage. 24390579
2014-12-27 13:59:00 The MHF complex, which is a heterotetramer that comprises two MHF1-MHF2 heterodimers, is remodeled by FANCM to favor recognition of branched DNA over dsDNA. 24699063
2014-09-13 12:01:00 CENPX assembly in living human cells, revealing a window in S phase and G2 in which de novo assembly of the complex from a soluble precursor occurs through a dynamic exchange mechanism. 24522885
2014-08-30 11:19:00 It discusses current knowledge of the biological roles of CENP-S and CENP-X and how their dual existence may be a common feature of CCAN (constitutive centromere-associated network) proteins. 24256282
2013-11-16 11:54:00 A long, positively charged patch exposed on the surface of the (MHF1-MHF2) complex plays a critical role in double-stranded DNA binding to chromatin. 23886707

名称对应

Type IDs
Synonymous CENP-X, D9, FAAP10, MHF2, STRA13
Gene
UniProtKB-ID: CENPX_HUMAN, J3QRS1_HUMAN
UniprotKB: A8MT69, J3QRS1
UniParc: UPI0000456B30, UPI000015D192, UPI000006FFE6, UPI0000E5A107
EMBL: AC137723, BC009571, BC011610, U95007, U95006
Ensembl: ENSG00000169689
KO: hsa:201254
Nucleutide sequences
EMBL-CDS: AAH09571.1, AAB53639.1, AAB53638.1, AAH11610.1
Ensembl_TRS: ENST00000580435, ENST00000306704, ENST00000392359, ENST00000584347
Protein sequencees
Ensembl_PRO: ENSP00000462015, ENSP00000302951, ENSP00000376168, ENSP00000464357
RefSeq: XP_016879816.1, NP_001317465.1, XP_016879818.1, NP_001257936.1, NP_659435.2, XP_024306407.1, XP_016879817.1, NP_001257935.1, XP_016879815.1
Others
UniRef100: UniRef100_A8MT69, UniRef100_J3QRS1
UniRef90: UniRef90_A0A2I3RH33, UniRef90_A8MT69
UniRef50: UniRef50_A0A2I3RH33, UniRef50_A8MT69
UniGene: Hs.37616
CCDS: CCDS32772.1, CCDS59303.1, CCDS59302.1

全选

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