| Type | Description |
|---|---|
| Definition | microtubule affinity regulating kinase 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-02 12:58:00 | Study shows that MARK2 is required to recentre spindles that are off-centred following actin disassembly, showing the close functional relationship between MARK2 and the actin network. These results suggest that, during both interphase and mitosis, MARK2 localizes at specialized membrane subdomains and coordinates actin and microtubule cytoskeletal changes, thus enabling normal cell division. | 31238822 |
| 2020-03-28 11:26:00 | Par1b-inhibition by CagA contributes to DNA Double Strand Breaks in H. pylori infected human primary gastric epithelial cells. | 30580666 |
| 2020-01-11 10:14:00 | Clustering of the CD44 extracellular domain by high-molecular-weight hyaluronan leads to recruitment of the polarity-regulating kinase PAR1b by the CD44 intracellular domain, which results in disruption of the Hippo signaling-inhibitory PAR1b-MST complex. | 31080060 |
| 2019-09-21 11:34:00 | The authors uncovered a novel role for MARK2 in maintaining the mitotic spindle at the cell's geometric center. | 29941476 |
| 2018-07-14 10:08:00 | In cell-based assays, Mark2 depletion indeed reduces Dvl gene expression and interrupts neural stem cell (NSCs) growth and differentiation, which are likely to be mediated through a decrease in class IIa HDAC phosphorylation and reduced H3K4ac and H3K27ac occupancies at the Dvl1/2 promoters. | 27714636 |
| Type | IDs |
|---|---|
| Synonymous | EMK-1, EMK1, PAR-1, Par-1b, Par1b |
| Gene |
UniProtKB-ID:
MARK2_HUMAN,
A8K2S4_HUMAN,
A0A140VJP1_HUMAN
UniprotKB:
Q7KZI7,
A8K2S4,
A0A140VJP1
UniParc:
UPI00004F6F01,
UPI00004F6F02,
UPI00004F6F07,
UPI0001639AC6,
UPI00004F6F04,
UPI00004F6F00,
UPI00004F6F05,
UPI00004F6F09,
UPI0000071CFD,
UPI000042704E,
UPI0000048D8A,
UPI000069648C,
UPI00004F6F08,
UPI00004F6F03,
UPI0000048D89,
UPI00015DA4E8,
UPI00004F6F06
EMBL:
Z25427,
BC008771,
BC084540,
AK290339,
AF387638,
HM005430,
AB188493,
X97630,
BT007342,
AP003780
Ensembl:
ENSG00000072518
KO:
hsa:2011
|
| Nucleutide sequences |
EMBL-CDS:
AAH08771.2,
CAA80914.1,
AAH84540.1,
AAP36006.1,
CAA66229.1,
AAK82368.1,
BAD37141.1,
BAF83028.1,
AEE61028.1
Ensembl_TRS:
ENST00000513765,
ENST00000350490,
ENST00000508192,
ENST00000361128,
ENST00000402010,
ENST00000509502,
ENST00000408948
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000385751,
ENSP00000425765,
ENSP00000423974,
ENSP00000386128,
ENSP00000355091,
ENSP00000421075,
ENSP00000294247
RefSeq:
XP_011543092.1,
XP_011543093.1,
XP_011543091.1,
XP_011543095.1,
NP_001156768.1,
XP_011543094.1,
NP_004945.4,
NP_001156769.1,
XP_011543099.1,
XP_011543097.1,
XP_011543098.1,
XP_011543100.1,
XP_016872799.1,
NP_001034558.2,
XP_016872800.1,
NP_059672.2,
XP_011543096.1
|
| Others |
UniRef100:
UniRef100_A0A140VJP1,
UniRef100_Q7KZI7,
UniRef100_A8K2S4
UniRef90:
UniRef90_A8K2S4,
UniRef90_Q7KZI7,
UniRef90_A0A140VJP1
UniRef50:
UniRef50_Q7KZI7-4,
UniRef50_Q7KZI7
UniGene:
Hs.567261
CCDS:
CCDS8051.2,
CCDS53651.1,
CCDS53649.1,
CCDS41665.1,
CCDS53650.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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