| Type | Description |
|---|---|
| Definition | sprouty related EVH1 domain containing 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-13 13:27:00 | Spred2 inhibits epithelialmesenchymal transition of colorectal cancer cells by impairing ERK signaling. | 32319644 |
| 2020-06-27 11:09:00 | SPRED2 deficiency impairs autophagy, leading to cardiac dysfunction and life-threatening arrhythmias. | 30771306 |
| 2020-05-09 13:31:00 | this study revealed more severe Ischemia-reperfusion injury in the lung grafts transplanted to Spred2-/- recipients | 31446154 |
| 2018-02-24 11:35:00 | Our findings show that miR-487a, mediated by heat shock factor 1, promotes proliferation and metastasis of Hepatocellular carcinoma (HCC) by PIK3R1 and SPRED2 binding, respectively. Our study provides a rationale for developing miR-487a as a potential prognostic marker or a potential therapeutic target against HCC. | 27827315 |
| 2018-01-06 10:40:00 | data indicate that Spred2 induces tumor cell death in an autophagy-dependent manner. | 27028858 |
| Type | IDs |
|---|---|
| Synonymous | Spred-2 |
| Gene |
UniProtKB-ID:
SPRE2_HUMAN,
B3KPL5_HUMAN
UniprotKB:
Q7Z698,
B3KPL5
UniParc:
UPI00001A833F,
UPI0000208591,
UPI000013E7B4
EMBL:
BC136334,
AC012370,
BC130292,
AY299090,
BC111495,
AK056479,
CH471053,
AK299079,
AC097503
Ensembl:
ENSG00000198369
KO:
hsa:200734
|
| Nucleutide sequences |
EMBL-CDS:
EAW99906.1,
EAW99905.1,
BAH12943.1,
AAI30293.1,
AAP59415.1,
AAI36335.1,
AAI11496.1,
BAG51727.1
Ensembl_TRS:
ENST00000356388,
ENST00000443619
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000348753,
ENSP00000393697
RefSeq:
NP_001121682.1,
XP_005264259.1,
XP_005264258.1,
XP_005264257.2,
NP_861449.2,
XP_016859065.1
|
| Others |
UniRef100:
UniRef100_Q7Z698,
UniRef100_B3KPL5
UniRef90:
UniRef90_Q5RDN2,
UniRef90_Q7Z698
UniRef50:
UniRef50_Q7Z698
UniGene:
Hs.59332
CCDS:
CCDS46308.1,
CCDS33211.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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