| Type | Description |
|---|---|
| Definition | phosphoinositide kinase, FYVE-type zinc finger containing |
| Date | Results | Publications |
|---|---|---|
| 2021-04-17 13:15:00 | Transcriptional Regulation of PIK3CD and PIKFYVE in T-Cell Acute Lymphoblastic Leukemia by and CK2. | 33467550 |
| 2019-11-02 12:02:00 | PIKfyve inhibition leads to impaired degradative capacity, ion dysregulation, abated autophagic flux and a massive enlargement of lysosomes. | 29661845 |
| 2017-10-14 13:00:00 | this study shows that PIKfyve coordinates the neutrophil immune response through the activation of the Rac GTPase | 28779020 |
| 2017-08-05 12:50:00 | in PC-3 cells inhibition of PIKfyve by apilimod or depletion by siRNA increased the secretion of the exosomal fraction. | 27438886 |
| 2017-06-24 10:12:00 | Here we identify the lipid kinase PIKfyve as a regulator of an alternative pathway that distributes engulfed contents in support of intracellular macromolecular synthesis during macropinocytosis, entosis, and phagocytosis. We find that PIKfyve regulates vacuole size in part through its downstream effector, the cationic transporter TRPML1 | 27623384 |
| Type | IDs |
|---|---|
| Synonymous | CFD, FAB1, HEL37, PIP5K, PIP5K3, ZFYVE29 |
| Gene |
UniProtKB-ID:
FYV1_HUMAN
UniprotKB:
Q9Y2I7
UniParc:
UPI0000366FD6,
UPI000022BDED,
UPI000006D123,
UPI0000E447E0
EMBL:
BC125053,
AB023198,
AC012362,
AK091482,
BC125052,
AC016697,
BC032389,
CH471063,
AY457063
Ensembl:
ENSG00000115020
KO:
hsa:200576
|
| Nucleutide sequences |
EMBL-CDS:
AAX93222.1,
AAY14870.1,
AAI25054.1,
AAI25053.1,
EAW70445.1,
EAW70444.1,
BAA76825.1,
BAC03674.1,
AAR19397.1,
AAH32389.1
Ensembl_TRS:
ENST00000264380,
ENST00000308862,
ENST00000392202,
ENST00000407449
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000376038,
ENSP00000308715,
ENSP00000384356,
ENSP00000264380
RefSeq:
XP_011509084.1,
XP_011509081.1,
XP_011509085.1,
XP_011509091.1,
XP_011509094.1,
XP_011509089.1,
XP_016859063.1,
NP_689884.1,
XP_016859062.1,
XP_011509087.1,
XP_016859059.1,
XP_011509090.1,
XP_011509086.1,
XP_016859060.1,
XP_011509080.1,
XP_016859061.1,
NP_001171471.1,
XP_016859057.1,
XP_011509092.1,
XP_011509088.1,
NP_055855.2,
XP_011509083.1,
XP_016859058.1,
XP_011509082.1
|
| Others |
UniRef100:
UniRef100_Q9Y2I7
UniRef90:
UniRef90_Q9Y2I7
UniRef50:
UniRef50_Q9Y2I7
UniGene:
Hs.744997
CCDS:
CCDS2382.1,
CCDS54431.1,
CCDS33368.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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