| Type | Description |
|---|---|
| Definition | CREB regulated transcription coactivator 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-16 12:41:00 | CRTC2 is unphosphorylated and therefore constitutively activated in LKB1-mutant non-small cell lung cance, where it promotes tumor growth, in part via the induction of the inhibitor of DNA binding 1. | 31355336 |
| 2020-02-01 13:31:00 | Results identified CRTC2 as a downstream substrate of constitutively activated p38. Constitutive, rather than transient, activation of p38 led to hyperphosphorylation of CRTC2, resulting in CRTC2 cytosolic relocation and subsequent inactivation of cyclic AMP response element (CRE)-mediated transcription. | 30782776 |
| 2019-06-01 11:18:00 | Data report crystal structures of a complex containing the CRTC2 CREB binding domain, the CREB basic leucine zipper domain and a CRE-containing DNA. The structures revealed that CRTC and CREB form a 2:2 complex on CRE-containing DNA, and CRTC interacts with both CREB and DNA through highly conserved residues. | 29733854 |
| 2018-10-06 11:58:00 | Study suggests that Creb/Crtc2 negatively regulates the Sirt1/Pparalpha/Fgf21 axis via the induction of miR-34a under diet-induced obesity and insulin-resistant conditions. | 29192248 |
| 2017-11-18 11:13:00 | Thyroid stimulating hormone activates CRTC2 via the pathway. | 28212844 |
| Type | IDs |
|---|---|
| Synonymous | TORC-2, TORC2 |
| Gene |
UniProtKB-ID:
CRTC2_HUMAN
UniprotKB:
Q53ET0
UniParc:
UPI00001A9468
EMBL:
BC053562,
AY360172,
BC028886,
AK223559,
AL358472
Ensembl:
ENSG00000160741
KO:
hsa:200186
|
| Nucleutide sequences |
EMBL-CDS:
AAH28886.1,
BAD97279.1,
AAH53562.1,
AAQ98857.1
Ensembl_TRS:
ENST00000368633
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000357622
RefSeq:
XP_016856065.1,
XP_016856068.1,
XP_005245006.1,
NP_859066.1,
XP_016856066.1,
XP_016856067.1,
XP_005245003.1,
XP_016856064.1
|
| Others |
UniRef100:
UniRef100_Q53ET0
UniRef90:
UniRef90_Q53ET0
UniRef50:
UniRef50_Q53ET0
UniGene:
Hs.406392
CCDS:
CCDS30875.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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