| Type | Description |
|---|---|
| Definition | FA core complex associated protein 20 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-06 13:58:00 | Acetylation modulates the Fanconi anemia pathway by protecting FAAP20 from ubiquitin-mediated proteasomal degradation. | 32763975 |
| 2018-01-06 12:05:00 | Study identify SCF-FBW7 as a ubiquitin E3 ligase that regulates the cellular FAAP20 levels and Fanconi anemia (FA) pathway. Deregulation of the GSK3beta- and FBW7-dependent FAAP20 degradation leads to a defect in the FA pathway, establishing a direct link between FBW7 and DNA repair. | 27232758 |
| 2016-01-30 10:50:00 | Data suggest Rev1 protein recognition mechanism by Fanconi anemia-associated protein 20 (FAAP20). | 26318859 |
| 2015-07-20 14:13:00 | FAAP20 contains a conserved ubiquitin-binding zinc-finger domain and binds K-63-linked ubiquitin chains in vitro. The FAAP20-UBZ domain is not required for interaction with FANCA, but is required for DNA-damage-induced chromatin loading of FANCA and the functional integrity of the Fanconi anemia pathway. | 22343915 |
| 2015-05-16 12:53:00 | FAAP20-ubiquitin interaction expands beyond the compact UBZ domain and requires the folding and interaction of the otherwise disordered C-terminal tail of FAAP20 for high-affinity binding. | 25414354 |
| Type | IDs |
|---|---|
| Synonymous | C1orf86, FP7162 |
| Gene |
UniProtKB-ID:
FAP20_HUMAN,
Q7Z4P6_HUMAN,
Q6ZRT9_HUMAN,
A0A024R0B3_HUMAN
UniprotKB:
Q6NZ36,
Q7Z4P6,
Q6ZRT9,
A0A024R0B3
UniParc:
UPI00001C0F17,
UPI00001B3F5F,
UPI000155D480,
UPI0000EE7BA1,
UPI000155D483,
UPI000155D481,
UPI000019863D,
UPI00004701BF,
UPI000163AC23
EMBL:
AF469129,
AK126870,
AK055593,
BC066360,
CH471183,
BC103992,
AF461903,
AK127994,
AL590822,
BC078145
Ensembl:
ENSG00000162585
KO:
hsa:199990
|
| Nucleutide sequences |
EMBL-CDS:
AAI03993.1,
AAH66360.1,
EAW56125.1,
BAC86730.1,
BAB70965.1,
AAQ04817.1,
AAP97719.1,
BAC87220.1,
EAW56128.1,
EAW56127.1
Gene_ORFName:
FP7162,
hCG_1770759
Ensembl_TRS:
ENST00000378543,
ENST00000414253,
ENST00000378546,
ENST00000400918
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000367804,
ENSP00000383709,
ENSP00000367808,
ENSP00000410450
RefSeq:
NP_001269599.1,
XP_006710484.1,
NP_001243876.2,
XP_011539216.1,
NP_001243874.2,
XP_016856046.1,
XP_016856045.1,
XP_016856042.1,
NP_001269602.2,
NP_001243875.2,
XP_016856044.1,
NP_001139782.1,
XP_006710482.1,
NP_001269600.1,
NP_872339.3,
XP_016856043.1,
XP_011539223.1,
NP_001269601.1,
XP_011539224.1
|
| Others |
UniRef100:
UniRef100_Q6NZ36,
UniRef100_A0A024R0B3,
UniRef100_Q6ZRT9,
UniRef100_Q7Z4P6
UniRef90:
UniRef90_A0A024R0B3,
UniRef90_Q6ZRT9,
UniRef90_A0A2R9AI31,
UniRef90_Q6NZ36
UniRef50:
UniRef50_F6S8H2,
UniRef50_Q6NZ36,
UniRef50_A0A2R9AI31
UniGene:
Hs.107101
CCDS:
CCDS38.2,
CCDS57965.1,
CCDS72687.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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