| Type | Description |
|---|---|
| Definition | retinal pigment epithelium 65 |
| Date | Results | Publications |
|---|---|---|
| 2019-10-19 10:45:00 | The pathological changes in the inner and outer segments layer of RPE65-/- mice were identified as diffuse hyperreflective changes on optical coherence tomography. | 30695025 |
| 2019-03-09 12:59:00 | Rod a-wave and cone b-wave amplitudes of electroretinograms were increased in Cntf (-/-) mice, but rod b-wave amplitudes were unchanged compared with those in WT mice. Up-regulated RPE65 and LRAT levels accelerated both the visual cycle rate and recovery rate of rod light sensitivity in Cntf (-/-) mice. | 30115683 |
| 2019-02-23 12:46:00 | These results indicate that a toxic gain-of-function induced by the D477G RPE65 substitution may play a role in the pathogenesis of this form of dominant retinitis pigmentosa | 29659842 |
| 2018-08-11 11:17:00 | The present study describes identification of CU239, a novel non-retinoid inhibitor of RPE65, a key enzyme in the visual cycle. Our data demonstrated that CU239 selectively inhibited isomerase activity of RPE65, with IC50 of 6muM. | 29684583 |
| 2017-12-23 11:07:00 | Study describes a mouse model of Leber's Congenital Amaurosis type 2 with mutation in Rpe65 gene. Functional and biochemical studies confirm that vitamin A metabolism and visual processing are disrupted in this model. | 27150101 |
| Type | IDs |
|---|---|
| Synonymous | 65kDa, A930029L06Rik, LCA2, Mord1, RP20, rd12 |
| Gene |
UniProtKB-ID:
RPE65_MOUSE
UniprotKB:
Q91ZQ5
UniParc:
UPI0000565C4C
EMBL:
BC130028,
AH011240,
CH466532,
AF410461,
AC163272
Ensembl:
ENSMUSG00000028174
KO:
mmu:19892
|
| Nucleutide sequences |
EMBL-CDS:
AAI30029.1,
AAL01119.1,
EDL11842.1,
AAL39096.1
Ensembl_TRS:
ENSMUST00000029824,
ENSMUST00000196999
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000029824,
ENSMUSP00000143654
RefSeq:
XP_006501228.1,
NP_084263.2
|
| Others |
UniRef100:
UniRef100_Q91ZQ5
UniRef90:
UniRef90_Q16518
UniRef50:
UniRef50_Q16518
UniGene:
Mm.131708
CCDS:
CCDS38683.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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