| Type | Description |
|---|---|
| Definition | RAR-related orphan receptor gamma |
| Date | Results | Publications |
|---|---|---|
| 2020-07-18 10:42:00 | CD4+ Tconv cells can differentiate into both RORgamma+ and Helios+ pTreg cells. | 31685531 |
| 2020-04-11 12:32:00 | Study reveals REV-ERBalpha as an antagonist of RORgammat. REV-ERBalpha and RORgammat share the same DNA binding motif. REV-ERB can inhibit the expression of RORgammat target genes and suppress RORgammat-driven Th17 cell differentiation. Treatment with a synthetic REV-ERB agonist delays the onset and impedes the progression of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. | 31455731 |
| 2020-01-25 13:56:00 | Regulated the mRNA and protein expression levels of IL-17A, RORgammaT, IL-22, T-bet, IL-10, and Foxp3 in the brain tissue. | 31522074 |
| 2020-01-11 10:54:00 | Authors also show that despite their sustained expression of Foxp3, Blimp-1(-/-) RORgammat(+)IL-17-producing Treg lose suppressor function and can promote intestinal inflammation, indicating that repression of Th17-associated cytokines by Blimp-1 is a crucial requirement for RORgammat(+) Treg function. | 30282028 |
| 2019-11-09 12:41:00 | this study shows that RORgammat represses IL-10 production in Th17 cells to maintain their pathogenicity in Inducing intestinal inflammation | 30478092 |
| Type | IDs |
|---|---|
| Synonymous | Nr1f3, RORgamma, TOR, Thor |
| Gene |
UniProtKB-ID:
RORG_MOUSE,
A0A0R4J096_MOUSE,
A0A0G2JGZ6_MOUSE
UniprotKB:
P51450,
A0A0R4J096,
A0A0G2JGZ6
UniParc:
UPI000002B2AB,
UPI0000028A04,
UPI000016C8DF,
UPI00001F0842,
UPI000016CA15
EMBL:
AF019658,
AF019660,
AF019656,
AF019657,
AJ132394,
U39071,
AF019659,
U43508,
AF019655,
AK153941,
AC164562,
AF163668,
BC014804
Ensembl:
ENSMUSG00000028150
KO:
mmu:19885
|
| Nucleutide sequences |
EMBL-CDS:
BAE32267.1,
AAB02582.1,
AAD46913.1,
AAC53501.1,
CAA10661.1,
AAB40709.1,
AAH14804.1
Ensembl_TRS:
ENSMUST00000200009,
ENSMUST00000029795,
ENSMUST00000197040
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000143610,
ENSMUSP00000029795,
ENSMUSP00000143763
RefSeq:
XP_006501225.3,
NP_035411.2,
XP_006501226.1,
XP_006501227.1,
NP_001280663.1
|
| Others |
UniRef100:
UniRef100_P51450,
UniRef100_A0A0G2JGZ6,
UniRef100_A0A0R4J096
UniRef90:
UniRef90_P51450
UniRef50:
UniRef50_P51450
UniGene:
Mm.4372
CCDS:
CCDS17591.1,
CCDS79971.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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