| Type | Description |
|---|---|
| Definition | ring finger protein 7 |
| Date | Results | Publications |
|---|---|---|
| 2019-10-26 11:29:00 | Study in transgenic mice with selective Sag deletion in myeloid lineage found that in contrast to in vitro observations those mice showed increased serum levels of proinflammatory cytokines and enhanced mortality in response to LPS. Sag-/- macrophages released less proinflammatory cytokines, neutrophils released more. Study revealed that Sag plays a differential role in the activation of macrophages and neutrophils. | 30574150 |
| 2019-05-18 10:57:00 | In the brain, Cul5 and Rbx2 are expressed in a similar fashion | 30269386 |
| 2018-04-14 11:52:00 | RBX2, a core component of the E3 ubiquitin ligase CRL5, is essential for retinal layering and function. RBX2 regulates the final cell position of rod bipolar cells, cone photoreceptors and Muller glia. Our data indicate that sustained RELN/DAB1 signaling, triggered by depletion of RBX2 or SOCS7 - a CRL5 substrate adaptor known to recruit DAB1 - causes rod bipolar cell misposition. | 29361558 |
| 2017-10-14 10:07:00 | SAG is a novel molecular target that regulates T-cell responses and that inhibiting neddylation with the clinically available small-molecule MLN4924 may represent a novel strategy to mitigate T-cell-mediated immunopathologies, such as graft-versus-host disease. | 27543965 |
| 2016-04-23 10:29:00 | Attenuation of SAG expression, exacerbates 4-hydroxy-2-nonenal-induced apoptosis and hypertrophy via a disruption of the cellular redox balance. | 25850934 |
| Type | IDs |
|---|---|
| Synonymous | Rbx2, SAG |
| Gene |
UniProtKB-ID:
RBX2_MOUSE,
D3Z392_MOUSE
UniprotKB:
Q9WTZ1,
D3Z392
UniParc:
UPI00015AA618,
UPI0000028D3F
EMBL:
AK003248,
BC011127,
AK146030,
AF092877,
AC161257
Ensembl:
ENSMUSG00000051234
KO:
mmu:19823
|
| Nucleutide sequences |
EMBL-CDS:
BAE26843.1,
AAH11127.1,
AAD25961.1,
BAB22666.1
Ensembl_TRS:
ENSMUST00000057500,
ENSMUST00000071301
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000052856,
ENSMUSP00000108581
RefSeq:
NP_001298064.1,
NP_035409.1
|
| Others |
UniRef100:
UniRef100_Q9WTZ1,
UniRef100_D3Z392
UniRef90:
UniRef90_Q9WTZ1,
UniRef90_D3Z392
UniRef50:
UniRef50_Q9UBF6,
UniRef50_A0A226NBK4
UniGene:
Mm.28235
CCDS:
CCDS40730.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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