| Type | Description |
|---|---|
| Definition | eukaryotic translation initiation factor 4E binding protein 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-01-25 14:01:00 | This study combines molecular dynamics simulations and discrete path sampling to construct energy landscapes for a doubly phosphorylated 4E-BP218-62. These results explain some interesting experimental observations, including the low stability of doubly phosphorylated 4E-BP2 and its moderate binding to eIF4E and the inability of phosphorylated Y54A/L59A to fold. | 31774674 |
| 2019-08-03 12:34:00 | Study demonstrated key roles for 4E-BP1 and 4E-BP2 during tumor development and during tumor hypoxia. These factors maintain an ability to slow tumor progression in prostate cancer in the face of constitutive mTOR activation arising from loss of PTEN, and are also important in promoting survival of hypoxic cells once cancer has developed | 29453322 |
| 2017-09-16 12:07:00 | Results suggest that IGF2BP3 promotes eIF4E-mediated translational activation through the reduction of EIF4E-BP2 via mRNA degradation, leading to enhanced cell proliferation. | 26522719 |
| 2017-08-26 12:30:00 | molecular dynamics simulations to investigate both the folded and unfolded states of 4E-BP2 under different phosphorylation states of T37 and T46 | 28068774 |
| 2015-03-28 11:51:00 | results highlight stabilization of a phosphorylation-induced fold as the essential mechanism for phospho-regulation of the 4E-BP:eIF4E interaction and exemplify a new mode of biological regulation mediated by intrinsically disordered proteins | 25533957 |
| Type | IDs |
|---|---|
| Synonymous | 4EBP2, PHASII |
| Gene |
UniProtKB-ID:
4EBP2_HUMAN,
A0A024QZM3_HUMAN
UniprotKB:
Q13542,
A0A024QZM3
UniParc:
UPI0000073D8C
EMBL:
BC005057,
CH471083,
BT007317,
BC050633,
L36056
Ensembl:
ENSG00000148730
KO:
hsa:1979
|
| Nucleutide sequences |
EMBL-CDS:
AAH50633.1,
AAH05057.1,
AAA62270.1,
AAP35981.1,
EAW54400.1,
EAW54402.1,
EAW54401.1
Gene_ORFName:
hCG_23653
Ensembl_TRS:
ENST00000373218
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000362314
RefSeq:
NP_004087.1
|
| Others |
UniRef100:
UniRef100_Q13542
UniRef90:
UniRef90_Q13542
UniRef50:
UniRef50_Q13542
UniGene:
Hs.621200,
Hs.730236
CCDS:
CCDS7303.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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