| Type | Description |
|---|---|
| Definition | eukaryotic translation initiation factor 4E binding protein 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-09 13:28:00 | Eukaryotic Initiation Factor 4E phosphorylation acts a switch for its binding to 4E-BP1 and mRNA cap assembly. | 32336547 |
| 2020-07-25 12:25:00 | Authors uncovered the role of cyclin-dependent kinase 4 (CDK4), a clinically validated kinase important for cell-cycle progression, in regulating cap-dependent translation via phosphorylation of the tumor suppressor 4E-BP1. | 31056462 |
| 2020-06-27 10:57:00 | The p-4E-BP1 expression, especially in Combined hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) (cHCC-CC) cases with a cholangiocarcinoma (CC) component, was a notable Akt/mTOR pathway-related factor associated with poor prognosis. | 31927624 |
| 2020-05-09 13:34:00 | Study showed higher expression of 4EB-P1 in prostate cancer (PCa) compared to benign tissues with local gradients in relation to the border of the tumor. These results suggest an important role of intratumor heterogeneity for the use of 4EBP1 as biomarkers in PCa. | 31885728 |
| 2020-03-21 12:31:00 | The most highly phosphorylated mitotic 4E-BP1 isoform (delta) did not interact with eIF4E, whereas a distinct 4E-BP1 phospho-isoform, EB-gamma, phosphorylated at Thr-70, Ser-83, and Ser-101, bound to eIF4E during mitosis. | 31201269 |
| Type | IDs |
|---|---|
| Synonymous | 4E-BP1, 4EBP1, BP-1, PHAS-I |
| Gene |
UniProtKB-ID:
4EBP1_HUMAN
UniprotKB:
Q13541
UniParc:
UPI000006E50A
EMBL:
BT007162,
AK312011,
BC058073,
CR456769,
CH471080,
AB044548,
L36055,
BC004459
Ensembl:
ENSG00000187840
KO:
hsa:1978
|
| Nucleutide sequences |
EMBL-CDS:
AAP35826.1,
EAW63341.1,
EAW63342.1,
AAA62269.1,
AAH04459.1,
BAG34949.1,
CAG33050.1,
BAB18650.1,
AAH58073.1
Ensembl_TRS:
ENST00000338825
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000340691
RefSeq:
NP_004086.1
|
| Others |
UniRef100:
UniRef100_Q13541
UniRef90:
UniRef90_Q13541
UniRef50:
UniRef50_Q13541
UniGene:
Hs.411641
CCDS:
CCDS6100.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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