| Type | Description |
|---|---|
| Definition | regulator of G-protein signaling 4 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-20 13:25:00 | RGS4 promotes allergen- and aspirin-associated airway hyperresponsiveness by inhibiting PGE2 biosynthesis. | 32199913 |
| 2020-08-22 15:25:00 | Regulator of G Protein Signaling 2 Facilitates Uterine Artery Adaptation During Pregnancy in Mice. | 31030617 |
| 2020-07-04 12:25:00 | RGS4 plays a prominent role in the maintenance of chronic pain symptoms in male and female mice. Using genetically modified mice, we show a dynamic role of RGS4 in recovery from symptoms of sensory hypersensitivity deriving from hindpaw inflammation or hindlimb nerve injury. We also demonstrate an important role of RGS4 actions in gene expression patterns induced by chronic pain states in the mouse thalamus. | 31308097 |
| 2019-09-07 12:42:00 | Genetic and pharmacological inhibition of RGS4 resulted in a significant decrease in SLC7A11 (xCT) expression and hypofunction of system xc(-) and reduced glutamatergic function in organotypic brain slice cultures. RGS4 deficit induces dysregulation and dysfunction of system xc(-), which further results in functional deficits of the glutamatergic system and subsequently to schizophrenia-related behavioral phenotypes. | 30279737 |
| 2018-11-03 10:38:00 | The nucleus-accumbens-specific knockdown of RGS4 significantly increased the behaviors associated with morphine and did so by phosphorylation of the GluR1 (Ser831) and NR2A (Tyr1325) glutamate receptors in the NAc. | 29754475 |
| Type | IDs |
|---|---|
| Synonymous | AA004315, AA597169, ESTM48, ESTM50 |
| Gene |
UniProtKB-ID:
RGS4_MOUSE,
Q5D078_MOUSE
UniprotKB:
O08899,
Q5D078
UniParc:
UPI0000027C02,
UPI0000003FA6
EMBL:
DQ346659,
BC003882,
AK039134,
AK030536,
DQ346661,
DQ346660,
AC115766,
AB004315,
BC055293
Ensembl:
ENSMUSG00000038530
KO:
mmu:19736
|
| Nucleutide sequences |
EMBL-CDS:
AAH03882.1,
BAA20400.1,
ABC94589.1,
BAC27009.1,
BAC30249.1,
AAH55293.1,
ABC94587.1,
ABC94588.1
Ensembl_TRS:
ENSMUST00000027991
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000027991
RefSeq:
NP_033088.2
|
| Others |
UniRef100:
UniRef100_O08899,
UniRef100_Q5D078
UniRef90:
UniRef90_O08899
UniRef50:
UniRef50_P49799
UniGene:
Mm.41642
CCDS:
CCDS15465.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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