| Type | Description |
|---|---|
| Definition | mixed lineage kinase domain like pseudokinase |
| Date | Results | Publications |
|---|---|---|
| 2021-04-13 10:11:00 | A novel neurodegenerative spectrum disorder in patients with MLKL deficiency. | 32358523 |
| 2021-02-13 13:27:00 | Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis. | 33318170 |
| 2020-12-19 13:42:00 | ID1 overexpression increases gefitinib sensitivity in non-small cell lung cancer by activating RIP3/MLKL-dependent necroptosis. | 32004572 |
| 2020-12-19 13:39:00 | The Trend of ripk1/ripk3 and mlkl Mediated Necroptosis Pathway in Patients with Different Stages of Prostate Cancer as Promising Progression Biomarkers. | 32162861 |
| 2020-10-31 13:13:00 | Understanding allosteric interactions in hMLKL protein that modulate necroptosis and its inhibition. | 31727943 |
| Type | IDs |
|---|---|
| Synonymous | hMLKL |
| Gene |
UniProtKB-ID:
MLKL_HUMAN
UniprotKB:
Q8NB16
UniParc:
UPI000004073C,
UPI0000071EE1
EMBL:
AK091708,
AC109599,
BC028141
Ensembl:
ENSG00000168404
KO:
hsa:197259
|
| Nucleutide sequences |
EMBL-CDS:
AAH28141.1,
BAC03728.1
Ensembl_TRS:
ENST00000308807,
ENST00000306247
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000303118,
ENSP00000308351
RefSeq:
XP_011521238.1,
NP_001135969.1,
NP_689862.1,
XP_005255891.1
|
| Others |
UniRef100:
UniRef100_Q8NB16
UniRef90:
UniRef90_Q8NB16
UniRef50:
UniRef50_Q8NB16
UniGene:
Hs.119878
CCDS:
CCDS45528.1,
CCDS32487.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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