| Type | Description |
|---|---|
| Definition | RB transcriptional corepressor like 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-04-25 12:37:00 | Overexpressing p130 or E2F4 in mMSCs could further improve the injured structure and function of epithelial cells in the lungs of ARDS mice as a result of improved differentiation of mMSCs into epithelial cells. | 30841904 |
| 2018-02-24 10:25:00 | Results show that ablation of the three members of the retinoblastoma family (RB1, p107 and p130) which targets a variety of adult lung epithelial cells, leads to spontaneous velopment of tumorlets, benign precancerous neuroendocrine (NE) lesions that do not progress to malignant tumors. Data imply the requirement of other oncogenic signaling pathways for full transformation in NE lung lesions mutant for the Rb family. | 27966456 |
| 2017-10-07 12:31:00 | Findings indicate that inactivation of the Rb family proteins (Rb, p107, and p130) in hematopoietic stem cells (HSCs) progressively impairs their homeostasis, which is rescued upon repression of suppressor of cytokine signaling 3 protein (Socs3) expression in triple knockout (TKO) HSCs. | 28550162 |
| 2017-07-22 13:36:00 | Loss of Rb 130 gene is associated with retinoblastoma. | 27750399 |
| 2015-11-28 10:45:00 | Deletion of Rb or p130 leads to impaired repression of Sox2, a defect amplified by inactivation of p53. Identify binding of pRb and p130 to an enhancer with crucial regulatory activity on Sox2 expression. | 25576924 |
| Type | IDs |
|---|---|
| Synonymous | PRB2, RBR-2, Rb2, p130 |
| Gene |
UniProtKB-ID:
RBL2_MOUSE,
A0A1B0GR06_MOUSE,
A0A1B0GRM0_MOUSE
UniprotKB:
Q64700,
A0A1B0GR06,
A0A1B0GRM0
UniParc:
UPI0000195403,
UPI0000023847,
UPI00001954B2
EMBL:
U47333,
U50850,
AC122441,
AK160027,
U36799
Ensembl:
ENSMUSG00000031666
KO:
mmu:19651
|
| Nucleutide sequences |
EMBL-CDS:
AAC52555.1,
AAC52598.1,
BAE35570.1,
AAB48991.1
Ensembl_TRS:
ENSMUST00000034091,
ENSMUST00000209518,
ENSMUST00000211136
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000034091,
ENSMUSP00000147327,
ENSMUSP00000147579
RefSeq:
NP_035380.3,
NP_001268929.1,
NP_001268930.1
|
| Others |
UniRef100:
UniRef100_A0A1B0GR06,
UniRef100_Q64700,
UniRef100_A0A1B0GRM0
UniRef90:
UniRef90_A0A1B0GR06,
UniRef90_O55081,
UniRef90_Q64700
UniRef50:
UniRef50_Q08999
UniGene:
Mm.235580
CCDS:
CCDS22518.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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