| Type | Description |
|---|---|
| Definition | deltex E3 ubiquitin ligase 3 |
| Date | Results | Publications |
|---|---|---|
| 2020-02-22 10:38:00 | DTX3, a novel E3 ligase for NOTCH2 was identified, and promoted its ubiquitination and degradation. DTX3 overexpression suppressed the proliferation and tumorigenicity of human oesophageal carcinoma cells. The analysis of tissue samples from patients revealed that the expression of DTX3 was low in esophageal cancer cells. | 31854042 |
| 2010-01-21 00:00:00 | We show here that both molecules (Deltex (DTX) and AIP4) interact and partially colocalize to endocytic vesicles, and that AIP4 targets DTX for lysosomal degradation. | 17028573 |
| 2005-06-09 14:40:00 | It is reported that BBAP and the human family of DTX proteins (DTX1, DTX2, and DTX3) function as E3 ligases based on their capacity for self-ubiquitination. | 12670957 |
| Type | IDs |
|---|---|
| Synonymous | RNF154, deltex3 |
| Gene |
UniProtKB-ID:
DTX3_HUMAN,
A0A024RB96_HUMAN
UniprotKB:
Q8N9I9,
A0A024RB96
UniParc:
UPI00000437C5,
UPI000006EA20
EMBL:
AL831941,
AK092085,
BC114498,
CH471054,
BC114441,
AK128752,
AK094385,
AY225126
Ensembl:
ENSG00000178498
KO:
hsa:196403
|
| Nucleutide sequences |
EMBL-CDS:
BAG54727.1,
CAD38593.2,
EAW97033.1,
BAC03801.1,
AAP57520.1,
BAC04344.1,
AAI14499.1,
AAI14442.1,
EAW97035.1,
EAW97034.1
Gene_ORFName:
hCG_39663
Ensembl_TRS:
ENST00000551632,
ENST00000548198,
ENST00000337737,
ENST00000548804
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000449294,
ENSP00000338050,
ENSP00000447873,
ENSP00000448696
RefSeq:
NP_001273174.1,
XP_005268754.1,
NP_848597.1,
XP_005268760.1,
XP_005268755.1,
XP_005268757.1,
XP_024304644.1,
XP_011536324.1,
NP_001273175.1
|
| Others |
UniRef100:
UniRef100_Q8N9I9
UniRef90:
UniRef90_Q8N9I9
UniRef50:
UniRef50_Q8N9I9
UniGene:
Hs.32374
CCDS:
CCDS66410.1,
CCDS41800.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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