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194908 Pld6

194908

Pld6

phospholipase D family, member 6

protein-coding

Mus musculus

基因描述

Type Description
Definition phospholipase D family, member 6

研究结论

Date Results Publications
2020-04-25 10:16:00 pre-piRNAs are generated by parallel Zucchini-dependent and -independent mechanisms; cleavage by Zucchini occurs at previously unrecognized consensus motifs on pre-pre-piRNAs, requires the RNA helicase Armitage, and is accompanied by 2'-O-methylation of pre-piRNAs 31996847
2018-11-17 11:56:00 PLD6 is a surface marker of undifferentiated spermatogonia in testes. 29113556
2017-09-23 11:38:00 MIWI (or PIWIL1) depletion had a smaller effect. In oocytes lacking PLD6 (or ZUCCHINI or MITOPLD), a mitochondrial nuclease/phospholipase involved in piRNA biogenesis in male germ cells, the piRNA level was decreased to 50% compared to wild-type. 28115634
2017-09-09 12:11:00 Drp1 binds a mitochondrial enzyme that produces phosphatidic acid, MitoPLD, and regulates mitochondrial division. 27635761
2017-08-19 12:30:00 The Dnmt3l mutation greatly reduced DNA methylation levels at most retrotransposons, but its impact on their RNA abundance was limited in prospermatogonia. In Pld6 mutant germ cells, although only a few retrotransposons exhibited reduced DNA methylation, many showed increased expression at the RNA level. 28749988

名称对应

Type IDs
Synonymous 4933433K01Rik, Gm10, Zuc, mZuc, mitoPLD
Gene
UniProtKB-ID: PLD6_MOUSE
UniprotKB: Q5SWZ9
UniParc: UPI0000483CD5, UPI0000429B2B
EMBL: BC119245, BC145052, AK077214, AK139586, AL596204
Ensembl: ENSMUSG00000043648
KO: mmu:194908
Nucleutide sequences
EMBL-CDS: AAI45053.1, AAI19246.1, BAC36687.1, BAE24077.1
Ensembl_TRS: ENSMUST00000125307
Protein sequencees
Ensembl_PRO: ENSMUSP00000115503
RefSeq: NP_898962.2, NP_001277212.1
Others
UniRef100: UniRef100_Q5SWZ9
UniRef90: UniRef90_Q5SWZ9
UniRef50: UniRef50_Q5SWZ9
UniGene: Mm.344651
CCDS: CCDS70199.1

全选

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