| Type | Description |
|---|---|
| Definition | RAS p21 protein activator 3 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-23 13:04:00 | Differential effects of RASA3 mutations on hematopoiesis are profoundly influenced by genetic background and molecular variant. | 33370780 |
| 2019-04-27 11:26:00 | RASA3 promoted proteasome-mediated IRF4 protein degradation by facilitating interaction of IRF4 with E3-ubiquitin ligase Cbl-b. Therefore, a RASA3-IRF4-Cbl-b pathway specifically directs pTh17 cell generation by balancing reciprocal Th17-Th2 cell programs. These findings indicate that a distinct molecular program directs pTh17 cell generation and reveals targets for treating pTh17 cell-related pathology and diseases. | 30446383 |
| 2018-06-23 10:39:00 | Rasa3 is a critical regulator of Rap1 in endothelial cells which controls adhesions properties and vascular lumen integrity; its specific endothelial cell inactivation results in occluded blood vessels, hemorrhages and early embryonic death in mouse, mimicking thus the Rasa3-/- mouse phenotype. | 29381707 |
| 2017-06-03 12:16:00 | these results support an important role for Rasa3 in PI3K-dependent integrin alphaIIbbeta3-mediated outside-in signaling and cell spreading. | 27903653 |
| 2015-09-26 11:48:00 | the function of RASA3 during megakaryopoiesis, megakaryocyte adhesion and migration as well as integrin signaling has been reported. | 25294679 |
| Type | IDs |
|---|---|
| Synonymous | AI326412, C86362, E130011G04, GAPIII, hlb381, scat |
| Gene |
UniProtKB-ID:
RASA3_MOUSE
UniprotKB:
Q60790
UniParc:
UPI00000E75A2
EMBL:
AB052362,
BC068297,
CH466566,
BC057300,
U20238,
AK141511
Ensembl:
ENSMUSG00000031453
KO:
mmu:19414
|
| Nucleutide sequences |
EMBL-CDS:
AAH68297.1,
EDL22155.1,
AAA93008.1,
BAB55802.1,
AAH57300.2,
BAE24707.1
Ensembl_TRS:
ENSMUST00000117551
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000112998
RefSeq:
XP_006508797.1,
NP_033051.2
|
| Others |
UniRef100:
UniRef100_Q60790
UniRef90:
UniRef90_Q60790
UniRef50:
UniRef50_Q60790
UniGene:
Mm.18517
CCDS:
CCDS40234.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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