| Type | Description |
|---|---|
| Definition | receptor-associated protein of the synapse |
| Date | Results | Publications |
|---|---|---|
| 2017-07-22 10:40:00 | The RING domain of rapsyn contains E3 ligase activity. Mutation of the RING domain that abolishes the enzyme activity inhibits rapsyn- as well as agrin-induced AChR clustering in heterologous and muscle cells. Further biological and genetic studies support a working model where rapsyn, a classic scaffold protein, serves as an E3 ligase to induce AChR clustering and NMJ formation, possibly by regulation of AChR neddylation | 27839998 |
| 2015-12-05 10:50:00 | Protein kinase CK2 interacts at the neuromuscular synapse with Rapsyn, Rac1, 14-3-3gamma, and Dok-7 proteins and phosphorylates the latter two. | 26198629 |
| 2015-08-22 10:42:00 | Plectin bridges acetylcholine receptors and intermediate filaments via direct interaction with the AChR-scaffolding protein rapsyn in an isoform-specific manner. | 25318670 |
| 2012-09-08 11:48:00 | Molecular modelling, immunoprecipitation and bimolecular fluorescence complementation approaches identify an alpha-helical stretch of rapsyn to be crucial for binding to the dimerisation and docking domain of type I. | 22331361 |
| 2012-08-04 10:23:00 | typical anchoring proteins of central excitatory synapses coimmunoprecipitate and colocalize with rapsyn | 22347480 |
| Type | IDs |
|---|---|
| Synonymous | 43kDa, Nraps, Raps, rapsyn |
| Gene |
UniProtKB-ID:
RAPSN_MOUSE
UniprotKB:
P12672
UniParc:
UPI0000020C13
EMBL:
AL672241,
BC111863,
J03962,
CH466519,
X15788
Ensembl:
ENSMUSG00000111579,
ENSMUSG00000002104
KO:
mmu:19400
|
| Nucleutide sequences |
EMBL-CDS:
CAA33789.1,
EDL27517.1,
AAI11864.1,
AAA40030.1
Ensembl_TRS:
ENSMUST00000215408,
ENSMUST00000050323
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000054150,
ENSMUSP00000149267
RefSeq:
XP_006499080.1,
XP_036015626.1,
NP_033049.2
|
| Others |
UniRef100:
UniRef100_P12672
UniRef90:
UniRef90_P12672
UniRef50:
UniRef50_Q13702-2
UniGene:
Mm.1272
CCDS:
CCDS16422.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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