| Type | Description |
|---|---|
| Definition | phosphoinositide-interacting regulator of transient receptor potential channels |
| Date | Results | Publications |
|---|---|---|
| 2020-05-09 13:32:00 | Pirt deficient female mice have an increased body weight and impaired glucose tolerance relative to wild-type (WT) mice. Pirt is dispensable for TRPM8-induced brown adipose tissue thermogenesis in vivo. | 30902502 |
| 2019-01-26 12:31:00 | Using comparative electrophysiology experiments, the study identified species-dependent differences between the human and mouse TRPM8-PIRT complexes. It found that human PIRT attenuated human TPRM8 conductance, unlike mouse PIRT, which enhanced mouse TRPM8 conductance. | 29724821 |
| 2018-12-01 11:31:00 | Results show that mechanical allodynia and thermal hyperalgesia were alleviated in Pirt-/- mice in chronic constriction injury (CCI) model. Taken together, Pirt together with transient receptor potential vanilloid channel 1 is involved in CCI-induced neuropathic pain. | 29808083 |
| 2017-02-18 10:57:00 | Pirt regulates TRPM8 channel activity by increasing the single channel conductance. | 26657057 |
| 2016-04-23 11:26:00 | These results demonstrate that Pirt is an endogenous regulator of P2X3 in bladder function. | 26151598 |
| Type | IDs |
|---|---|
| Synonymous | A530088H08Rik |
| Gene |
UniProtKB-ID:
PIRT_MOUSE,
Q3UFA4_MOUSE
UniprotKB:
Q8BFY0,
Q3UFA4
UniParc:
UPI000004445E,
UPI00005AC812
EMBL:
AK041182,
AK084056,
EU447173,
AK051645,
BC147296,
AK148754,
AK051285,
BC147297,
CH466601
Ensembl:
ENSMUSG00000048070
KO:
mmu:193003
|
| Nucleutide sequences |
EMBL-CDS:
BAC39108.1,
BAC30853.1,
BAC34704.1,
AAI47297.1,
AAI47298.1,
BAC34593.1,
ACC60974.1,
EDL10416.1,
BAE28657.1
Ensembl_TRS:
ENSMUST00000123434
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000128117
RefSeq:
NP_848771.1,
XP_011247124.1,
XP_006532642.1
|
| Others |
UniRef100:
UniRef100_Q3UFA4,
UniRef100_Q8BFY0
UniRef90:
UniRef90_Q3UEZ1,
UniRef90_Q8BFY0
UniRef50:
UniRef50_Q3UEZ1,
UniRef50_Q8BFY0
UniGene:
Mm.440256
CCDS:
CCDS24849.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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