| Type | Description |
|---|---|
| Definition | purine rich element binding protein B |
| Date | Results | Publications |
|---|---|---|
| 2021-01-02 12:48:00 | Purbeta promotes hepatic glucose production by increasing Adcy6 transcription. | 31918924 |
| 2017-04-29 10:29:00 | site-directed mutagenesis revealed several basic amino acid residues in the intermolecular (R267) and intramolecular (K82 and R159) subdomains that are essential for Purbeta transcriptional repressor function in Acta2 promoter-reporter assays. In keeping with their diminished Acta2 repressor activity in fibroblasts, purified Purbeta variants containing an R267A mutation exhibited reduced binding affinity for purine-ric... | 27064749 |
| 2013-09-14 10:28:00 | This structural arrangement suggests that the cooperative assembly of the dimeric Purbeta repressor on the sense strand of the ACTA2 enhancer is dictated by the association of each subdomain with distinct purine-rich binding sites within the enhancer. | 23724822 |
| 2010-10-23 10:43:00 | These findings suggest that the highly conserved modular repeats of Purbeta fold to form a core functional domain, which mediates the specific and high affinity binding of the protein to single-stranded DNA. | 20728429 |
| 2010-04-12 12:17:00 | Overexpression of Purbeta, but not Puralpha, significantly downregulated GnRH1 mRNA levels in transiently transfected GT1-7 cells, suggesting that Purbeta acts as a repressor of GnRH1 gene transcription. | 19996387 |
| Type | IDs |
|---|---|
| Synonymous | 2310015K15Rik, AA114818, Cager-2, D11Bwg0414e |
| Gene |
UniProtKB-ID:
PURB_MOUSE
UniprotKB:
O35295
UniParc:
UPI00000294B6
EMBL:
AF017630,
AL646020
Ensembl:
ENSMUSG00000094483
KO:
mmu:19291
|
| Nucleutide sequences |
EMBL-CDS:
AAB71859.1
Ensembl_TRS:
ENSMUST00000179343
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000136957
RefSeq:
NP_035351.1
|
| Others |
UniRef100:
UniRef100_O35295
UniRef90:
UniRef90_O35295
UniRef50:
UniRef50_O35295
UniGene:
Mm.390332
CCDS:
CCDS24420.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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