| Type | Description |
|---|---|
| Definition | protein tyrosine phosphatase, receptor type, O |
| Date | Results | Publications |
|---|---|---|
| 2020-03-28 11:30:00 | Data suggest that tyrosine (Tyr399) in Phosphatase (PTPROt) might participate in regulating the activity of this phosphatase toward src Kinases (Src). | 30622194 |
| 2017-10-28 12:24:00 | Using loss-of-function and gain-of-function approaches, we show that PTPRO promotes the formation of excitatory synapses | 28871037 |
| 2017-10-14 11:46:00 | PTPROt thus functions as an obligate haploinsufficient TS in CLL, where its expression levels determine its role as a promoter or inhibitor of the tumorigenic process in mice. Partial loss of PTPROt generates the strongest disease phenotype, suggesting that its intermediate expression levels in CLL are selected for. | 28166196 |
| 2017-08-05 13:15:00 | TLR4 and NF-kappaB/p65 phosphorylation was significantly enhanced in PTPRO over-expressing cells, while significantly down-regulated in PTPRO knockout cells. PTPRO plays ital roles in atherosclerosis (AS) via promoting ox-LDL induced oxidative stress and cell apoptosis through TLR4/NF-kappaB pathway. | 28578349 |
| 2016-05-28 11:30:00 | PTPRO plays an important role in FH by interacting with TLR4. | 26303994 |
| Type | IDs |
|---|---|
| Synonymous | D28, GLEPP1, PTPBK, PTPROt, PTPU2, PTPoc, PTPphi, Ptpn15, R-PTP-O |
| Gene |
UniProtKB-ID:
PTPRO_MOUSE,
A0A0N4SUY2_MOUSE,
E9PVJ6_MOUSE,
E9Q4I1_MOUSE
UniprotKB:
E9Q612,
A0A0N4SUY2,
E9PVJ6,
E9Q4I1
UniParc:
UPI0001B2C155,
UPI00001F457A,
UPI000002141A,
UPI0001B2C156
EMBL:
AC093120,
AC144767,
BC052743,
AC163627
Ensembl:
ENSMUSG00000030223
KO:
mmu:19277
|
| Nucleutide sequences |
EMBL-CDS:
AAH52743.1
Ensembl_TRS:
ENSMUST00000077115,
ENSMUST00000203914,
ENSMUST00000167002,
ENSMUST00000167679
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000076364,
ENSMUSP00000144870,
ENSMUSP00000131764,
ENSMUSP00000127112
RefSeq:
NP_001157873.1,
NP_001157875.1,
XP_036021848.1,
XP_036021847.1,
XP_036021849.1,
NP_001157874.1,
NP_035346.3,
XP_036021846.1
|
| Others |
UniRef100:
UniRef100_E9Q612,
UniRef100_E9Q4I1,
UniRef100_E9PVJ6,
UniRef100_A0A0N4SUY2
UniRef90:
UniRef90_E9Q612
UniRef50:
UniRef50_E9Q612
UniGene:
Mm.186361,
Mm.491536
CCDS:
CCDS20664.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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