| Type | Description |
|---|---|
| Definition | protein tyrosine phosphatase, receptor type, N polypeptide 2 |
| Date | Results | Publications |
|---|---|---|
| 2019-01-12 10:58:00 | Relative to wildtype mice, IRS2 levels in phogrin-knockout mice islets decreased by 44%. When phogrin was silenced by shRNA in pancreatic beta-cell lines, glucose-induced insulin signaling led to proteasomal degradation of IRS2 via a negative feedback mechanism. | 29483197 |
| 2016-12-17 10:19:00 | The deletion of IA-2 and IA-2beta results in multiple pathophysiologic changes and represents a unique in vivo model for studying the effect of hormone and neurotransmitter reduction on known and still unrecognized targets. | 25861885 |
| 2016-01-16 10:45:00 | Data show that miRNAs are involved in regulating the expression of the major type 1 diabetes (T1D) autoantigens IA-2, IA-2beta, and GAD65 enzyme. | 26148972 |
| 2014-03-01 13:03:00 | Membrane-proximal ectodomain of phogrin was produced as a recombinant protein and characterized' results showed that it is a properly folded monomeric domain. | 23016632 |
| 2010-01-21 00:00:00 | Phogrin and IA-2 function as essential regulators of autocrine insulin action in pancreatic beta-cells. | 19073770 |
| Type | IDs |
|---|---|
| Synonymous | 4930425H11Rik, IA2beta, PTP-NP, Phol, mKIAA0387, phogrin |
| Gene |
UniProtKB-ID:
PTPR2_MOUSE,
Q3UU93_MOUSE,
A3KN68_MOUSE
UniprotKB:
P80560,
Q3UU93,
A3KN68
UniParc:
UPI0000F3B8DA,
UPI00005ABE52,
UPI00006CA368
EMBL:
BN000296,
AC159645,
U82439,
AC159625,
BN000297,
BN000300,
BN000295,
AC164641,
BN000314,
BC133678,
BN000308,
AC159648,
BN000299,
U57345,
BN000303,
BN000312,
BN000301,
BN000306,
AK138655,
BN000309,
BN000294,
BN000311,
BN000307,
BN000305,
BN000293,
BN000313,
BN000310,
BN000302,
BN000304,
BN000315,
AC169503,
BN000298,
AC161242,
AC160634
Ensembl:
ENSMUSG00000056553
KO:
mmu:19276
|
| Nucleutide sequences |
EMBL-CDS:
CAG23871.1,
AAB06945.1,
AAB39996.1,
BAE23734.1,
AAI33679.1
Ensembl_TRS:
ENSMUST00000070733,
ENSMUST00000190247
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000064046,
ENSMUSP00000139978
RefSeq:
XP_011242321.1,
NP_035345.2
|
| Others |
UniRef100:
UniRef100_A3KN68,
UniRef100_P80560,
UniRef100_Q3UU93
UniRef90:
UniRef90_P80560
UniRef50:
UniRef50_Q92932
UniGene:
Mm.206054
CCDS:
CCDS36576.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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