| Type | Description |
|---|---|
| Definition | argonaute RISC catalytic component 3 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-16 15:56:00 | Human Argonaute2 and Argonaute3 are catalytically activated by different lengths of guide RNA. | 33122430 |
| 2017-12-16 10:34:00 | Data show that recombinant AGO3 loaded with miR-20a cleaves complementary target RNAs. | 29040713 |
| 2015-01-17 10:16:00 | Study uncovers a first example of a vertebrate protein factor, Argonaute-3, specifically affecting the guide-to-passenger-strand ratio of the miRNA let-7a. A multi-layered mechanism for the observed impact of Ago3 on the let-7a-3p passenger strand expression and activity is proposed. | 24100239 |
| 2013-09-14 12:12:00 | The N-terminal domain of Ago3 inhibits cleavage activity. AAs 1-64 are largely unstructured & form a large loop surrounding an area containing two helices & another unstructured loop. | 23665583 |
| 2013-09-14 11:34:00 | The Ago3 PIWI domain is slicing competent but our Ago3 model suggests multiple interactions between residues in the PIWI & N domains that may increase protein rigidity or invoke other properties that contribute to Ago3's observed slicing deficiency. | 23748378 |
| Type | IDs |
|---|---|
| Synonymous | EIF2C3 |
| Gene |
UniProtKB-ID:
AGO3_HUMAN,
B4E1P5_HUMAN
UniprotKB:
Q9H9G7,
B4E1P5
UniParc:
UPI000013CBE4,
UPI0000141361,
UPI00017A8715
EMBL:
AL138787,
BC025769,
AK022827,
AK303929,
AL139286
Ensembl:
ENSG00000126070
KO:
hsa:192669
|
| Nucleutide sequences |
EMBL-CDS:
BAB14262.1,
BAG64857.1
Ensembl_TRS:
ENST00000246314,
ENST00000373191
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000362287,
ENSP00000246314
RefSeq:
XP_016856012.1,
XP_016856013.1,
XP_016856014.1,
XP_011539184.1,
NP_079128.2,
XP_016856016.1,
XP_005270633.1,
XP_011539181.1,
XP_016856017.1,
NP_803171.1,
XP_005270632.1,
XP_016856015.1
|
| Others |
UniRef100:
UniRef100_Q9H9G7,
UniRef100_B4E1P5
UniRef90:
UniRef90_B4E1P5,
UniRef90_Q9H9G7
UniRef50:
UniRef50_Q9H9G7,
UniRef50_A0A2I3GHI1
UniGene:
Hs.657659
CCDS:
CCDS399.1,
CCDS400.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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