| Type | Description |
|---|---|
| Definition | hexamethylene bis-acetamide inducible 1 |
| Date | Results | Publications |
|---|---|---|
| 2018-11-24 12:05:00 | Trypanosoma cruzi (T. cruzi) infected mice heterozygous for hexamethylene bis-acetamide inducible 1 (Hexim1) gene have compromised cardiac function, altered expression of both pro- and anti-inflammatory cytokines, and increased inflammation and fibrosis. The profound exacerbation of pathologic findings in the tissues of heart, lung, spleen, and intestines suggests a protective role for Hexim1 in T. cruzi infection. | 28951318 |
| 2017-11-04 10:49:00 | Decreased Hexim-1 expression does not alter cholesterol metabolism in ApoE null background after high fat diet. However, it promotes stable atherosclerotic plaque and decreased steatosis by promoting the anti-inflammatory TGFbeta pathway and blocking the expression of the inducible and pro-inflammatory expression of SOCS3 respectively. | 28013147 |
| 2016-12-17 11:01:00 | Hexim1 selectively modulates leptin-mediated signal transduction pathways in the hypothalamus. | 26859361 |
| 2015-07-25 10:58:00 | conclude that HEXIM1 could prevent RV hypertrophy, at least in part, via suppression of myocardial angiogenesis through down-regulation of HIF-1alpha and VEGF in the myocardium under hypoxic condition | 25301555 |
| 2014-02-01 11:10:00 | HEXIM1 re-expression results in the induction of angiogenesis that allows for the co-ordination of tissue growth and angiogenesis during physiological hypertrophy | 23585471 |
| Type | IDs |
|---|---|
| Synonymous | 7330426E13Rik, CLP-1, Clp1, HIS1 |
| Gene |
UniProtKB-ID:
HEXI1_MOUSE
UniprotKB:
Q8R409
UniParc:
UPI000002839B
EMBL:
AK134535,
AY090614,
AL731805
Ensembl:
ENSMUSG00000048878
KO:
mmu:192231
|
| Nucleutide sequences |
EMBL-CDS:
AAM09026.1,
BAE22173.1
Ensembl_TRS:
ENSMUST00000053063
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000057339
RefSeq:
NP_620092.1
|
| Others |
UniRef100:
UniRef100_Q8R409
UniRef90:
UniRef90_Q8R409
UniRef50:
UniRef50_O94992
UniGene:
Mm.8763
CCDS:
CCDS25513.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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