| Type | Description |
|---|---|
| Definition | prostaglandin I receptor (IP) |
| Date | Results | Publications |
|---|---|---|
| 2019-07-13 12:28:00 | Removal of the IP receptors unmasks a protective role of mPGES-1-derived PGE2 in limiting injury-induced vascular hyperplasia. EP4, in the endothelial compartment, is essential to promote reendothelialization and restrain neointimal formation after injury. | 29599139 |
| 2017-08-05 12:56:00 | results provide evidence that PGI2/IP signaling suppresses the pathway of allergic airway inflammation | 27456482 |
| 2017-06-10 10:12:00 | Data (including data from studies using transgenic mice, an murine experimental model of diabetes, and mouse/human cell lines) suggest prostaglandin I2 receptor (Ptgir) is involved in insulin secretion in pancreatic beta-cells and in permselectivity in glomerular podocytes; the mechanism appears to involve regulation of post-translational phosphorylation of nephrin. | 26868296 |
| 2016-12-17 10:50:00 | Deletion of the I prostanoid receptor had no effect on the attenuation of atherogenesis by mPGES-1 deletion in the low-density lipoprotein receptor knockout mice. | 27440004 |
| 2015-01-03 12:54:00 | Prostacyclin promotes the up-regulation of Nox4 in endothelial cells, which opens up a novel strategy that protects and enhances endothelial cell functions in cardiovascular disease, such as repair after myocardial infarction or other ischemic conditions. | 24450852 |
| Type | IDs |
|---|---|
| Synonymous | IP, PGI2 |
| Gene |
UniProtKB-ID:
PI2R_MOUSE,
Q8CC99_MOUSE
UniprotKB:
P43252,
Q8CC99
UniParc:
UPI00000E93D3,
UPI0000024688
EMBL:
D26157,
AK033567,
BC094386
Ensembl:
ENSMUSG00000043017
KO:
mmu:19222
|
| Nucleutide sequences |
EMBL-CDS:
AAH94386.1,
BAA05144.1,
BAC28365.1
Ensembl_TRS:
ENSMUST00000144408
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000122080
RefSeq:
XP_006539733.1,
NP_032993.2
|
| Others |
UniRef100:
UniRef100_P43252,
UniRef100_Q8CC99
UniRef90:
UniRef90_E9PY53,
UniRef90_P43252
UniRef50:
UniRef50_E9PY53,
UniRef50_P43119
UniGene:
Mm.287572
CCDS:
CCDS20857.2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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