| Type | Description |
|---|---|
| Definition | neuroligin 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-13 13:23:00 | Alternative splicing at neuroligin site A regulates glycan interaction and synaptogenic activity. | 32915137 |
| 2020-03-28 12:56:00 | A phosphorylation-dependent molecular mechanism that regulates NLGN1 and PSD-95 binding. | 31138690 |
| 2019-11-16 11:26:00 | Nlgn1 performs two key functions in excitatory synapses by distinct molecular mechanisms. NMDA receptor-dependent long term potentiation (LTP) requires trans-synaptic binding of postsynaptic neuroligin-1 to presynaptic beta-neurexins but not the cytoplasmic sequences of neuroligins. Postsynaptic NMDA receptor-mediated responses involve a neurexin-independent mechanism that requires the neuroligin-1 cytoplasmic sequences. | 30871858 |
| 2019-08-10 11:03:00 | This study provides a novel approach to understand the molecular basis of Fragile X syndrome by linking the dysregulated synaptic expression of NLGNs with FMRP | 30056576 |
| 2019-03-30 10:16:00 | To characterize the possible contribution of NLGN1 to inflammatory pain, the present study analyzed the changes of NLGN1 expression after intraplantar injection of complete Freund's adjuvant (CFA). Our data revealed an activity-dependent recruitment of NLGN1 into synapses, which was essential for NMDAR hyperfunction and pain hypersensitivity. | 30049666 |
| Type | IDs |
|---|---|
| Synonymous | 6330415N05Rik, BB179718, NL1, Nlg1, mKIAA1070 |
| Gene |
UniProtKB-ID:
NLGN1_MOUSE,
E9QK34_MOUSE
UniprotKB:
Q99K10,
E9QK34
UniParc:
UPI000019C3FF,
UPI000019C400,
UPI0000D636ED
EMBL:
AC124099,
AK122433,
AC099863,
AC127365,
AC100381,
AC107806,
BC005523,
AC162794,
AC109281,
AC108852,
AC123660
Ensembl:
ENSMUSG00000063887
KO:
mmu:192167
|
| Nucleutide sequences |
EMBL-CDS:
AAH05523.1,
BAC65715.1
Ensembl_TRS:
ENSMUST00000193603,
ENSMUST00000075054,
ENSMUST00000108308,
ENSMUST00000191835
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000074565,
ENSMUSP00000142200,
ENSMUSP00000103944,
ENSMUSP00000142086
RefSeq:
XP_036018842.1,
XP_030108326.1,
NP_001344026.1,
XP_036018847.1,
XP_006535482.1,
XP_006535488.1,
XP_006535486.1,
NP_001344024.1,
XP_006535484.1,
XP_036018845.1,
XP_006535483.1,
XP_036018841.1,
XP_036018843.1,
XP_036018844.1,
XP_036018839.1,
XP_006535478.1,
XP_006535481.1,
XP_036018848.1,
XP_006535479.1,
NP_619607.2,
NP_001156859.1,
XP_006535485.1,
XP_036018846.1,
XP_036018840.1,
NP_001344025.1,
XP_006535487.1
|
| Others |
UniRef100:
UniRef100_E9QK34,
UniRef100_Q99K10
UniRef90:
UniRef90_Q62765
UniRef50:
UniRef50_Q62765
UniGene:
Mm.316080
CCDS:
CCDS17268.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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