| Type | Description |
|---|---|
| Definition | ATPase, H+/K+ transporting, nongastric, alpha polypeptide |
| Date | Results | Publications |
|---|---|---|
| 2020-05-16 11:42:00 | H,K-ATPase type 2 regulates renal salt and potassium metabolism during gestation, controlling plasma volume expansion and blood pressure. | 31913688 |
| 2017-07-01 11:44:00 | After 4 days of K+ restriction HKA2 KO mice exhibit hypokalemia and hypotension. | 27562425 |
| 2014-05-03 12:05:00 | HKA2-null mice did not accumulate K(+) in their extracellular compartment. | 23440459 |
| 2012-09-22 11:32:00 | HKA2-null mice fed a normal diet have 2-fold higher K(+) renal excretion during rest. Under K(+) restriction, their urinary K(+) loss is 40% higher during the activity period. | 22459151 |
| 2010-01-21 00:00:00 | These results show that nongastric H-K-ATPase is required for acidification of luminal prostate fluids, thereby providing a strong in vivo correlate of previous functional expression studies demonstrating that it operates as a proton pump. | 16525125 |
| Type | IDs |
|---|---|
| Synonymous | Atp1al1, HKalpha2, cHKA |
| Gene |
UniProtKB-ID:
AT12A_MOUSE
UniprotKB:
Q9Z1W8
UniParc:
UPI00001E9037
EMBL:
AF100169,
BC109011,
AF350499
Ensembl:
ENSMUSG00000022229
KO:
mmu:192113
|
| Nucleutide sequences |
EMBL-CDS:
AAI09012.1,
AAL68709.1,
AAD03421.1
Ensembl_TRS:
ENSMUST00000007340
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000007340
RefSeq:
NP_619593.2
|
| Others |
UniRef100:
UniRef100_Q9Z1W8
UniRef90:
UniRef90_P54708
UniRef50:
UniRef50_P06685
UniGene:
Mm.273271
CCDS:
CCDS27148.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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