| Type | Description |
|---|---|
| Definition | PGAM family member 5, mitochondrial serine/threonine protein phosphatase |
| Date | Results | Publications |
|---|---|---|
| 2020-11-21 13:26:00 | Empagliflozin improves diabetic renal tubular injury by alleviating mitochondrial fission via AMPK/SP1/PGAM5 pathway. | 32777444 |
| 2020-08-22 15:28:00 | Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics. | 32439975 |
| 2019-12-14 12:25:00 | Elevated PGAM5 expression in hepatocellular carcinoma is associated with a poor prognostic phenotype. Knocking down PGAM5 in hepatocellular carcinoma cells inhibited cell viability and enhanced chemosensitivity. | 30250224 |
| 2019-11-30 12:18:00 | PGAM5-mediated mitophagy in turn leads to a self-perpetuating escalation of DeltaPsi depolarization. Loss of the mitophagy-based damage-enhancing loop under PGAM5-deficient conditions breaks this vicious cycle, leading to improved mitochondrial homeostasis. | 31168659 |
| 2019-11-09 11:59:00 | have identified phosphoglycerate mutase family member 5 (PGAM5), a serine/threonine specific protein phosphatase, as a regulator of Lipin-1 activity. Activation of endogenous PGAM5, promoted dephosphorylation and nuclear accumulation of Lipin-1 | 30642635 |
| Type | IDs |
|---|---|
| Synonymous | BXLBV68 |
| Gene |
UniProtKB-ID:
PGAM5_HUMAN
UniprotKB:
Q96HS1
UniParc:
UPI0000406AB5,
UPI00001400B6
EMBL:
AC135586,
EU249757,
AF357523,
BC008196
Ensembl:
ENSG00000247077
KO:
hsa:192111
|
| Nucleutide sequences |
EMBL-CDS:
ABX39494.1,
AAK60627.1,
AAH08196.1
Ensembl_TRS:
ENST00000317555,
ENST00000498926
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000438465,
ENSP00000321503
RefSeq:
NP_001164014.1,
NP_612642.2,
NP_001164015.1
|
| Others |
UniRef100:
UniRef100_Q96HS1
UniRef90:
UniRef90_Q96HS1
UniRef50:
UniRef50_Q96HS1
UniGene:
Hs.102558
CCDS:
CCDS9280.1,
CCDS53845.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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