| Type | Description |
|---|---|
| Definition | patched 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-08-15 19:03:00 | Using primordial germ cell migration in mouse as a developmental model study demonstrates that specific heterocomplexes of Ptch2/Gas1 and Ptch1/Boc mediate the process of Smo de-repression with different kinetics. Moreover, Ptch2-mediated Hedgehog signalling induces the phosphorylation of Creb and Src proteins in parallel to Gli induction, identifying a previously unknown Ptch2-specific signal pathway. | 32332736 |
| 2020-07-04 12:35:00 | Results show that hedgehog protein (Hedgehog) receptors patched 1 protein (Ptch1) and patched 2 protein (Ptch2) elicit independent responses, which enable multimodal Hedgehog signaling to simultaneously regulate epithelial stem cells (SCs) maintenance and differentiation. | 31145830 |
| 2019-07-13 11:46:00 | However, genetic removal of Ptch2 in our Ptch12/2MMmice did not affect the severity of the observed phenotype. This suggests that Ptch2 does not play a functional role in regulating HH signaling activity during kidney development, but serves as a specific marker of the onset ofUPJO. | 29109083 |
| 2019-04-20 11:43:00 | The N-terminal and C-terminal of Ptch2 interacted noncovalently but did not repress the Hh pathway. | 30166346 |
| 2018-01-27 11:25:00 | during Hedgehog signaling, ligand binding inhibits Patched by trapping it in an inactive conformation, a mechanism that explains the dramatically reduced activity of oncogenic Patched1 mutants. | 27647915 |
| Type | IDs |
|---|---|
| Synonymous | ptc2 |
| Gene |
UniProtKB-ID:
PTC2_MOUSE
UniprotKB:
O35595
UniParc:
UPI0000001587
EMBL:
AJ133483,
AB010833,
AJ133482,
AJ133485,
AJ133484,
AL671866
Ensembl:
ENSMUSG00000028681
KO:
mmu:19207
|
| Nucleutide sequences |
EMBL-CDS:
CAC88120.1,
BAA24691.1
Ensembl_TRS:
ENSMUST00000030443
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000030443
RefSeq:
NP_001299832.1,
NP_032984.1
|
| Others |
UniRef100:
UniRef100_O35595
UniRef90:
UniRef90_O35595
UniRef50:
UniRef50_Q9Y6C5
UniGene:
Mm.287037
CCDS:
CCDS18526.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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