| Type | Description |
|---|---|
| Definition | proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) |
| Date | Results | Publications |
|---|---|---|
| 2019-08-24 11:29:00 | Overexpression of PA28alpha and concomitant upregulation of PA28beta protein reduces depressive-like behavior and enhances learning and memory in female mice. The overexpression of PA28alpha does not increase PA28alphabeta-dependent proteasome activity but could still be linked to its protective functions upon oxidative stress and proteinopathy. | 30400847 |
| 2019-05-11 11:16:00 | In mouse models of both genetic and dietary obesity, stimulation of proteasomal activity by exogenously expressing Nrf1 or by treatment with the proteasome activator PA28alpha in BAT resulted in improved insulin sensitivity. In conclusion, Nrf1 emerges as a novel guardian of brown adipocyte function, providing increased proteometabolic quality control for adapting to cold or to obesity. | 29400713 |
| 2018-12-22 11:31:00 | PA28a overexpression quadruples the number of surviving photoreceptors in the inferior retina of mice with inherited retinal degeneration. | 29712894 |
| 2018-03-24 11:52:00 | Study clarifies the subunit composition and arrangement of PA28ab and provides key insights into the assembly of an asymmetric complex from two highly homologous subunits. Differential scanning fluorimetry experiments and activity assays classify PA28alpha4beta3 as most stable and most active, indicating that this assembly might represent the physiologically relevant species. | 28867616 |
| 2013-11-16 11:52:00 | Inhibiting accumulation of PA28alpha using microRNA counteracted the removal of damaged proteins demonstrating that PA28alphabeta has a role required for resetting the levels of protein damage at the transition from self-renewal to cell differentiation. | 23459332 |
| Type | IDs |
|---|---|
| Synonymous | AW413925, PA28a |
| Gene |
UniProtKB-ID:
PSME1_MOUSE,
Q5HZK3_MOUSE
UniprotKB:
P97371,
Q5HZK3
UniParc:
UPI0000028D5B
EMBL:
U60328,
AK019390,
AK008514,
AB053120,
AB007136,
AK150708,
AK150975,
BC088981,
D87909
Ensembl:
ENSMUSG00000022216
KO:
mmu:19186
|
| Nucleutide sequences |
EMBL-CDS:
BAB25712.1,
BAA28835.1,
AAC53295.1,
BAB31696.1,
BAB47403.1,
BAA22039.1,
BAE29786.1,
BAE30004.1,
AAH88981.1
Ensembl_TRS:
ENSMUST00000174259
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000134735
RefSeq:
NP_035319.1
|
| Others |
UniRef100:
UniRef100_P97371
UniRef90:
UniRef90_P97371
UniRef50:
UniRef50_Q06323
UniGene:
Mm.830
CCDS:
CCDS36931.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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