| Type | Description |
|---|---|
| Definition | proteasome (prosome, macropain) subunit, beta type 10 |
| Date | Results | Publications |
|---|---|---|
| 2018-10-13 11:16:00 | Our results showed that immunoproteasome subunit LMP10 expression and its trypsin-like activity were significantly upregulated in the retinas and serum of Ang II-infused mice and in the serum from patients with hypertensive retinopathy..this study provided novel evidence demonstrating that LMP10 is a positive regulator of NF-kB signaling, which contributes to Ang II-induced retinopathy. | 29499566 |
| 2017-09-30 12:09:00 | The knockout of beta2i ameliorates DOCA/salt-induced cardiac fibrosis and inflammation, and may be a novel potential therapeutic target for hypertensive heart diseases. | 28478040 |
| 2012-09-01 11:02:00 | LMP7 and MECL1 regulate cytokine expression, suggesting this system represents a novel mechanism for the regulation of cytokines and cytokine signaling | 22398747 |
| 2011-10-22 10:24:00 | Findings strongly support the concept that LMP7/MECL-1 proteasomes subunits actively function to regulate LPS-induced NO production by affecting the TRIF/TRAM pathway. | 21455681 |
| 2010-01-21 00:00:00 | phenotype of hyperproliferation of T cells lacking both MECL-1 and LMP7 implicates a specific role for immunoproteasomes in T cell proliferation that is not obviously connected to MHC class I Ag processing | 16547243 |
| Type | IDs |
|---|---|
| Synonymous | Mecl-1, Mecl1 |
| Gene |
UniProtKB-ID:
PSB10_MOUSE
UniprotKB:
O35955
UniParc:
UPI00000238FE
EMBL:
D85562,
Y10875,
BC004730,
U77784,
U77785,
D85561
Ensembl:
ENSMUSG00000031897
KO:
mmu:19171
|
| Nucleutide sequences |
EMBL-CDS:
BAA22856.1,
AAH04730.1,
AAB87637.1,
CAA71825.1,
AAB86994.1,
BAA22855.1
Ensembl_TRS:
ENSMUST00000034369
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000034369
RefSeq:
NP_038668.2
|
| Others |
UniRef100:
UniRef100_O35955
UniRef90:
UniRef90_O35955
UniRef50:
UniRef50_P40306
UniGene:
Mm.787
CCDS:
CCDS22621.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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