| Type | Description |
|---|---|
| Definition | prosaposin |
| Date | Results | Publications |
|---|---|---|
| 2018-12-01 10:25:00 | Accumulating evidence suggests that PGRN is essential for proper lysosomal function, but the precise mechanisms involved are not known. Here, we show that PGRN facilitates neuronal uptake and lysosomal delivery of prosaposin (PSAP), the precursor of saposin peptides that are essential for lysosomal glycosphingolipid degradation. | 28541286 |
| 2018-09-15 11:28:00 | Both PSAP reduction and overexpression lead to significantly elevated extracellular progranulin (PGRN) levels. Intriguingly, PSAP knockdown increases PGRN monomers, whereas PSAP overexpression increases PGRN oligomers, partly through a protein-protein interaction. | 27356620 |
| 2017-12-16 10:58:00 | Data show that matrix (ECM) stiffness leads to mechano-signal transduction in mesenchymal stem cells (MSC), which promotes mammary tumor growth in part through secretion of the signaling protein prosaposin. | 28972074 |
| 2016-03-12 11:02:00 | Data suggested that the abundance of Psap in sperm sample may be a sensitive endpoint to predict PCB exposure. | 26045750 |
| 2015-12-26 11:49:00 | Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin. | 26370502 |
| Type | IDs |
|---|---|
| Synonymous | AI037048, SGP-1 |
| Gene |
UniProtKB-ID:
SAP_MOUSE,
Q3TXJ0_MOUSE,
Q3UAS4_MOUSE,
B2RUD7_MOUSE,
Q3UFE8_MOUSE,
Q3UE29_MOUSE,
E9PZ00_MOUSE,
Q3TWM9_MOUSE,
Q8BFQ1_MOUSE
UniprotKB:
Q61207,
Q3TXJ0,
Q3UAS4,
B2RUD7,
Q3UFE8,
Q3UE29,
E9PZ00,
Q3TWM9,
Q8BFQ1
UniParc:
UPI0001747A8D,
UPI00005AC902,
UPI00005AD29D,
UPI00000280BE,
UPI00000EBAC4,
UPI0001989314,
UPI00005ACAB8,
UPI00005AD30D
EMBL:
AK166909,
AK159982,
AK159840,
AK159861,
AK150331,
AK159266,
AK152355,
AK152117,
U27340,
AK160015,
S36200,
AK159910,
AK151943,
AK160024,
BC141089,
AK166849,
AK167237,
AK152134,
AK151234,
AK166879,
AK159333,
AK151529,
AK159244,
AK160046,
AK152505,
AK159451,
AK159589,
AK159528,
AK159510,
AK151907,
AC079082,
AK159685,
AK088369,
AK151525,
AK151173,
AK159198,
AK166744,
AK159657,
AK152819,
BC145359,
AK159604,
AK148545,
AK159915,
AK152203,
U57999,
AK159487,
AK166811,
AK151034,
AK151852,
AK152126,
AK152557,
AK167014,
AK145802,
AK159728,
AK159341,
AK159936,
AK151686,
AK166920,
AK151891,
AK159720,
AK152605,
AK159492,
S71616,
AK159862,
AK161313,
AK159530,
AK167418,
AK159463,
AK159994,
AK151251,
AK148152,
AK159457,
AK167111,
AK166700,
AK159877,
AK151230,
AK159108,
AK089998,
AK159384,
AK159427,
AK167025,
AK170416,
AK159221,
AK166707,
AK160877,
AK159622,
AK135637,
AK149785
Ensembl:
ENSMUSG00000004207
KO:
mmu:19156
|
| Nucleutide sequences |
EMBL-CDS:
AAB31059.1,
AAA92567.1,
AAB02695.1,
AAB22175.1,
BAE34908.1,
BAE34926.1,
BAE35126.1,
BAE30240.1,
BAE30226.1,
BAE30477.1,
AAI41090.1,
BAE28613.1,
BAE29082.1,
BAE35237.1,
BAE41782.1,
BAE35159.1,
BAE35266.1,
BAE30967.1,
BAE34998.1,
BAE31311.1,
BAE35209.1,
BAE35074.1,
BAE35288.1,
BAE39090.1,
BAE35142.1,
AAI45360.1,
BAE31032.1,
BAE30222.1,
BAE29473.1,
BAE35449.1,
BAE35567.1,
BAE34824.1,
BAE28378.1,
BAE35322.1,
BAE36065.1,
BAE35099.1,
BAE35435.1,
BAE30975.1,
BAE30775.1,
BAE39190.1,
BAE30473.1,
BAE30742.1,
BAE35496.1,
BAE35533.1,
BAE38955.1,
BAE39259.1,
BAE35473.1,
BAE38986.1,
BAE35157.1,
BAE35588.1,
BAE26658.1,
BAE39068.1,
BAE30176.1,
BAE35436.1,
BAE35418.1,
BAE35561.1,
BAE34893.1,
BAE35122.1,
BAE31147.1,
BAE35003.1,
BAE35315.1,
BAE39117.1,
BAE36317.1,
BAE22597.1,
BAC40308.1,
BAC41035.1,
BAE39038.1,
BAE34946.1,
BAE38961.1,
BAE35039.1,
BAE30051.1,
BAE31272.1,
BAE35544.1,
BAE35104.1,
BAE39506.1,
BAE30788.1,
BAE35478.1,
BAE35223.1,
BAE39198.1,
BAE35094.1,
BAE30961.1,
BAE30819.1,
BAE39359.1,
BAE39110.1,
BAE30610.1,
BAE31522.1,
BAE31352.1
Ensembl_TRS:
ENSMUST00000179238,
ENSMUST00000165878,
ENSMUST00000105465
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000137476,
ENSMUSP00000126407,
ENSMUSP00000101105
RefSeq:
NP_035309.3,
XP_017169338.1,
XP_017169337.1,
NP_001139596.1,
NP_001139595.1,
NP_001139594.1,
XP_036011585.1,
XP_036011584.1,
NP_001139592.1,
NP_001139593.1
|
| Others |
UniRef100:
UniRef100_E9PZ00,
UniRef100_Q3UE29,
UniRef100_Q8BFQ1,
UniRef100_B2RUD7,
UniRef100_Q61207,
UniRef100_Q3UAS4,
UniRef100_Q3TXJ0
UniRef90:
UniRef90_Q61207,
UniRef90_Q8BFQ1
UniRef50:
UniRef50_P07602
UniGene:
Mm.277498
CCDS:
CCDS35911.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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||||
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