| Type | Description |
|---|---|
| Definition | legumain |
| Date | Results | Publications |
|---|---|---|
| 2020-01-18 10:25:00 | Lgmn was upregulated in lung tissues of PAH mice subjected to hypoxia(HySu) plus SU5416. Deletion of Lgmn systemically inhibits the development of PAH by diminishing ECM protein accumulation in PAs from HySu-treated mice.The synthetic specific Lgmn inhibitor RR-11a protects against PAH. Lgmn promotes ECM protein deposition in PAs involved in activating TGF-beta1. | 30676070 |
| 2019-12-14 11:35:00 | Study shows that BDNF-mediated Akt directly phosphorylates AEP on T322 and blocks AEP activation, sequestering it in lysosomes. Viral delivery of unphosphorylated T322A mutant into brain of young alpha-SNCA mice accelerates alpha-syn N103 cleavage in alpha-SNCA-Tg mice. Data support the hypothesis that a decrease in BDNF/TrkB signaling in neurodegenerative diseases abolishes p-AEP T322, resulting in AEP upregulation an... | 30135302 |
| 2019-09-07 10:56:00 | AEP mediates tau-splicing imbalance in tauopathies via cleaving SRPK2. | 30373880 |
| 2019-07-27 12:47:00 | Asparagine endopeptidase knockout (AEP KO) displayed lower anxiety-like behavior and more advanced exploratory behavior, reduced depressive-like behaviors, and elevated spatial learning and memory ability. Enhanced synaptic plasticity as well as the increased expressions of SYP and PSD-95 proteins in hippocampus were shown in AEP KO mice. BDNF protein was reduced and NF-kappaB p65 protein was increased in their hippoca... | 30030107 |
| 2019-02-23 13:08:00 | findings thus support that AEP-mediated cleavage of alpha-Syn at N103 is required for the association and activation of MAO-B, mediating Parkinson's disease pathogenesis. | 29769405 |
| Type | IDs |
|---|---|
| Synonymous | AEP, AI746452, AU022324, Prsc1 |
| Gene |
UniProtKB-ID:
LGMN_MOUSE,
Q3UE99_MOUSE,
A2RTI3_MOUSE
UniprotKB:
O89017,
Q3UE99,
A2RTI3
UniParc:
UPI0000021B31,
UPI00005AC8E0
EMBL:
AK149666,
AJ000990,
BC132519,
BC132515,
AF044266
Ensembl:
ENSMUSG00000021190
KO:
mmu:19141
|
| Nucleutide sequences |
EMBL-CDS:
CAA04439.1,
AAF21659.1,
BAE29012.1,
AAI32520.1,
AAI32516.1
Ensembl_TRS:
ENSMUST00000110020,
ENSMUST00000021607
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000021607,
ENSMUSP00000105647
RefSeq:
NP_001365804.1,
NP_035305.1
|
| Others |
UniRef100:
UniRef100_O89017
UniRef90:
UniRef90_O89017
UniRef50:
UniRef50_Q99538
UniGene:
Mm.17185
CCDS:
CCDS26119.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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