| Type | Description |
|---|---|
| Definition | eukaryotic translation initiation factor 2-alpha kinase 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-02-15 10:39:00 | phosphorylation of eIF2alpha was mediated via protein kinase R (PKR), but further investigation revealed that PKR activation, phosphorylation of eIF2alpha, and translational arrest were uncoupled during viral infection | 31213553 |
| 2019-12-14 10:21:00 | C5aR2 promotes NLRP3 activation by amplifying dsRNA-dependent PKR expression, which is an important NLRP3-activating factor. | 30971430 |
| 2019-06-22 12:02:00 | The data suggest that proteasomal degradation alone is responsible for PKR degradation during mouse adenovirus type 1 infection. | 31015330 |
| 2019-05-11 13:04:00 | Reduced cholesterol results in PKR-dependent eIF2alpha phosphorylation, which enhances c-Jun translation, leading in turn to higher levels of JNK-mediated c-Jun phosphorylation. | 30091670 |
| 2019-01-26 11:01:00 | The authors saw no impact of PKR deficiency on macrophage activation in vitro or during the course of Mycobacterium tuberculosis infection in vivo. | 29436711 |
| Type | IDs |
|---|---|
| Synonymous | 2310047A08Rik, 4732414G15Rik, AI467567, AI747578, Pkr, Prkr, Tik |
| Gene |
UniProtKB-ID:
E2AK2_MOUSE
UniprotKB:
Q03963
UniParc:
UPI0000003F73
EMBL:
U09927,
U09924,
U09926,
U09917,
AK028602,
U09925,
U09921,
U09914,
U09915,
U09918,
U09920,
U09919,
U09916,
U09922,
U09923,
M65029,
U09928,
M93567
Ensembl:
ENSMUSG00000024079
KO:
mmu:19106
|
| Nucleutide sequences |
EMBL-CDS:
AAC24729.1,
AAA39885.1,
AAA40150.1,
BAC26027.1
Ensembl_TRS:
ENSMUST00000024884
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000024884
RefSeq:
NP_035293.1,
XP_006523926.1
|
| Others |
UniRef100:
UniRef100_Q03963
UniRef90:
UniRef90_Q03963
UniRef50:
UniRef50_P19525
UniGene:
Mm.378990
CCDS:
CCDS28980.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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