| Type | Description |
|---|---|
| Definition | mitogen-activated protein kinase 8 interacting protein 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-10-05 12:44:00 | A point mutation in the Jip1 gene selectively blocks JIP1-mediated JNK activation. JIP1-mediated JNK activation contributes to the regulation of hippocampus-dependent, NMDAR-mediated synaptic plasticity and learning. | 29540552 |
| 2018-06-09 11:56:00 | These interactions are required for SRC-induced activation of VAV and the subsequent engagement of a JIP1-tethered JNK signaling module. | 28930674 |
| 2018-01-27 10:11:00 | Phosphorylation of KLC1 at Thr466 increased in aged brains, and JIP1 binding to kinesin-1 decreased, suggesting that APP transport is impaired by aging. Authors conclude that phosphorylation of KLC1 at Thr466 regulates the velocity of transport of APP by kinesin-1 by modulating its interaction with JIP1b. | 29093025 |
| 2016-03-19 11:21:00 | It mediates Alzheimer-disease like pathologies in AICD-Tg mice and that JNK signaling may contribute to amyloid-independent mechanisms of AD pathogenesis. | 26022769 |
| 2015-06-27 13:46:00 | Enhanced fast-velocity and efficient high-frequency APP anterograde transport observed in neurons are mediated by novel roles of JIP1b. | 25165140 |
| Type | IDs |
|---|---|
| Synonymous | IB1, JIP-1, Jip1, Prkm8ip, Skip, mjip-2a |
| Gene |
UniProtKB-ID:
JIP1_MOUSE,
Q3UI81_MOUSE,
Q6GQW8_MOUSE
UniprotKB:
Q9WVI9,
Q3UI81,
Q6GQW8
UniParc:
UPI000002AC56,
UPI0000022B25,
UPI000002AC58,
UPI000002AC57,
UPI000002AC59,
UPI00005AC5E5,
UPI00003B564B
EMBL:
AF332075,
BC072578,
AK147033,
AF003115,
AF109771,
AF109769,
AF109770,
AF054611,
AF109768,
AF332076
Ensembl:
ENSMUSG00000027223
KO:
mmu:19099
|
| Nucleutide sequences |
EMBL-CDS:
AAK56104.1,
AAD38349.1,
AAD38347.1,
AAK56103.1,
AAD38348.1,
AAD22580.1,
AAD38346.1,
AAB66317.1,
BAE27625.1,
AAH72578.1
Ensembl_TRS:
ENSMUST00000050312,
ENSMUST00000111279
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000050773,
ENSMUSP00000106910
RefSeq:
NP_001189375.1,
NP_001189374.1,
NP_035292.2
|
| Others |
UniRef100:
UniRef100_Q6GQW8,
UniRef100_Q3UI81,
UniRef100_Q9WVI9
UniRef90:
UniRef90_Q9WVI9,
UniRef90_Q9WVI9-4
UniRef50:
UniRef50_Q9WVI9-4,
UniRef50_Q9WVI9
UniGene:
Mm.2720
CCDS:
CCDS57180.1,
CCDS16446.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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