| Type | Description |
|---|---|
| Definition | protein kinase, cGMP-dependent, type I |
| Date | Results | Publications |
|---|---|---|
| 2020-05-09 12:12:00 | These results suggest that cGKI in vascular smooth muscle cells should be targeted by therapies designed to protect brain tissue against ischemic stroke. | 31423931 |
| 2020-04-11 12:29:00 | Increased oxidation of PKGIalpha to its disulfide-activated state found in pulmonary arteries from mice with hypoxic pulmonary arterial hypertension (PH) or lungs from patients. It caused by chronic hypoxia, and it limits progression of PH by pulmonary vasodilation that counters and offsets maladaptive vasoconstriction, and also disulfide PKGIalpha is protective by preventing maladaptive growth and fibrosis signaling. | 31186362 |
| 2019-12-14 10:09:00 | Study shows that mice carrying gain-of-function mutation in PRKG1 recapitulate the human early-onset thoracic aortic disease, and that pathological changes in the aorta are, at least in part, caused by oxidative stress, revealing that increased basal PKG activity induces oxidative stress in the aorta, raising concern about the widespread clinical use of PKG-activating drugs. | 31387997 |
| 2019-04-06 11:52:00 | the NF-kappaB/miR-155-5p/PKG1 axis may be crucial in the pathogenesis of inflammatory vascular diseases, such as atherosclerotic intimal hyperplasia and preeclamptic hypertension. | 30104414 |
| 2019-01-19 11:40:00 | Prkg1 cascade role in platelet activation and thrombosis. | 30327468 |
| Type | IDs |
|---|---|
| Synonymous | AW125416, CGKI, Gm19690, Prkg1b, Prkgr1b |
| Gene |
UniProtKB-ID:
KGP1_MOUSE,
Q8BND1_MOUSE
UniprotKB:
P0C605,
Q8BND1
UniParc:
UPI00000EB208,
UPI000002960A
EMBL:
AC103405,
AF084547,
AC122548,
AC116507,
AK083991,
AC102751,
BC113162,
AC119158,
AC108399
Ensembl:
ENSMUSG00000052920
KO:
mmu:19091
|
| Nucleutide sequences |
EMBL-CDS:
AAI13163.1,
AAD16044.1,
BAC39087.1
Ensembl_TRS:
ENSMUST00000065067,
ENSMUST00000073581
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000067576,
ENSMUSP00000073268
RefSeq:
XP_006526831.1,
NP_035290.1,
NP_001013855.1
|
| Others |
UniRef100:
UniRef100_P0C605
UniRef90:
UniRef90_P0C605
UniRef50:
UniRef50_Q13976-2
UniGene:
Mm.381170
CCDS:
CCDS29745.1,
CCDS29746.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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