| Type | Description |
|---|---|
| Definition | protein phosphatase 5, catalytic subunit |
| Date | Results | Publications |
|---|---|---|
| 2020-04-04 10:44:00 | During inflammatory response to the bacterial LPS in the heart of transgenic mouse model with cardiac myocyte directed overexpression of protein phosphatase 5 (PP5) basal cardiac contractility was reduced, but LPS-induced cardiac dysfunction was less pronounced compared to wild type mice. PP5 increases stress tolerance of cardiac myocytes by downregulation of NF-kappaB signaling and upregulation of HSP25 expression. | 31425567 |
| 2019-09-21 11:07:00 | PP5 is a significant negative regulator on the regulation of bone and cartilage development. | 29434189 |
| 2019-06-29 12:53:00 | PP5 directly interacts with and dephosphorylates p53 at multiple serine/threonine residues, resulting in inhibition of p53-mediated transcriptional activity. | 30262665 |
| 2018-12-22 10:28:00 | PP5 binds and dephosphorylates the elastic N2B-unique sequence (N2Bus) of titin in cardiomyocytes. PP5 is pathologically elevated and likely contributes to hypo-phosphorylation of N2Bus in failing human hearts. Furthermore, Hsp90-activated PP5 interacts with components of a sarcomeric, N2Bus-associated, mechanosensor complex, and blocks mitogen-activated protein-kinase signaling in this complex. | 29343782 |
| 2015-04-18 11:18:00 | Mice with inactivated protein phosphatase 5 have decreased adipogenesis. | 25437352 |
| Type | IDs |
|---|---|
| Synonymous | AU020526, PP5 |
| Gene |
UniProtKB-ID:
PPP5_MOUSE
UniprotKB:
Q60676
UniParc:
UPI0000020CE6
EMBL:
BC003744,
U12204,
AF018262,
CH466654,
AC148976
Ensembl:
ENSMUSG00000003099
KO:
mmu:19060
|
| Nucleutide sequences |
EMBL-CDS:
EDL42060.1,
AAB18613.1,
AAH03744.1,
AAB70573.1
Ensembl_TRS:
ENSMUST00000003183
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000003183
RefSeq:
XP_030098096.1,
XP_017177532.1,
NP_035285.2,
XP_006539726.1
|
| Others |
UniRef100:
UniRef100_Q60676
UniRef90:
UniRef90_P53041
UniRef50:
UniRef50_P53041
UniGene:
Mm.3294,
Mm.475000
CCDS:
CCDS20859.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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