| Type | Description |
|---|---|
| Definition | periplakin |
| Date | Results | Publications |
|---|---|---|
| 2019-12-07 12:14:00 | Study in a mouse model of lung fibrosis induced by bleomycin found that Ppl expression was downregulated in the whole lung and in alveolar epithelial cells (AECs) after bleomycin-induced injury. Deletion of Ppl reduced lung fibrosis after bleomycin injury by promoting antiinflammatory cytokine expression and profoundly altering cellular signaling in AECs, including activation, and TGF-beta/smad pathway activation. | 29515024 |
| 2010-01-21 00:00:00 | Data suggest that the primary role of periplakin may not relate to the physiology of the cornified cell envelope in epidermal keratinocytes but may reside in the challenges, which normal laboratory mice do not encounter. | 15226441 |
| 2010-01-21 00:00:00 | Periplakin interferes with G protein activation by the melanin-concentrating hormone receptor-1 by binding to the proximal segment of the receptor C-terminal tail | 15590649 |
| 2010-01-21 00:00:00 | Thus, combined loss of the cornified envelope proteins not only impairs the epidermal barrier, but also changes the composition of T cell subpopulations in the skin. | 18166659 |
| Type | IDs |
|---|---|
| Synonymous | AW553870 |
| Gene |
UniProtKB-ID:
PEPL_MOUSE,
Q3UQD7_MOUSE,
G5E898_MOUSE
UniprotKB:
Q9R269,
Q3UQD7,
G5E898
UniParc:
UPI00005AC14F,
UPI0000029526,
UPI000024E069
EMBL:
AC163723,
AC124576,
AF126834,
AF116522,
AF116523,
AF013715,
AK014700,
AF116521,
AF116520,
AF116519,
AK142562
Ensembl:
ENSMUSG00000039457
KO:
mmu:19041
|
| Nucleutide sequences |
EMBL-CDS:
BAB29510.1,
AAF29436.2,
AAD20642.1,
AAC40068.1,
BAE25105.1
Ensembl_TRS:
ENSMUST00000035672
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000039360
RefSeq:
NP_032935.2
|
| Others |
UniRef100:
UniRef100_Q9R269,
UniRef100_G5E898
UniRef90:
UniRef90_Q9R269,
UniRef90_D4A5T8
UniRef50:
UniRef50_O60437
UniGene:
Mm.266875
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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