| Type | Description |
|---|---|
| Definition | polymerase (DNA directed), epsilon |
| Date | Results | Publications |
|---|---|---|
| 2019-09-28 11:23:00 | We engineered a conditional PoleP286R allele. PoleP286R/+ embryonic fibroblasts exhibited a striking mutator phenotype and immortalized more efficiently. PoleP286R/+ mice were born at Mendelian ratios but rapidly developed lethal cancers of diverse lineages, yielding the most cancer-prone monoallelic model described to date, to our knowledge. | 30124468 |
| 2019-02-16 10:12:00 | Loss of epsilon is associated with embryonic lethality and extensive developmental abnormalities, leukopenia, and tumor predisposition. | 29754823 |
| 2014-04-12 11:46:00 | A missense mutation in Rev7 disrupts formation of Polzeta, impairing mouse development and repair of genotoxic agent-induced DNA lesions. | 24356953 |
| 2010-01-21 12:47:00 | Findings distinguish Pol epsilon and delta functions in vivo and reveal tissue-specific requirements for DNA replication fidelity. | 19805137 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
DPOE1_MOUSE,
Q80XH7_MOUSE,
Q3UR94_MOUSE
UniprotKB:
Q9WVF7,
Q80XH7,
Q3UR94
UniParc:
UPI0000195852,
UPI000005FB69,
UPI00005AC0A5
EMBL:
AK141674,
AF126380,
AC118260,
AF126387,
AF126383,
AF126384,
AF126395,
AF126392,
AF126382,
AF126396,
AF126391,
AF126389,
AF126388,
BC048166,
AF126390,
AF126385,
AF126377,
BC063246,
AF126398,
AC123699,
AF123502,
AF126386,
AF126379,
AF126393,
AF126394,
AF126378,
AF126397,
AF126381
Ensembl:
ENSMUSG00000007080
KO:
mmu:18973
|
| Nucleutide sequences |
EMBL-CDS:
AAD46482.1,
AAD45244.1,
AAH63246.1,
AAH48166.1,
BAE24794.1
Ensembl_TRS:
ENSMUST00000007296
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000007296
RefSeq:
NP_035262.2
|
| Others |
UniRef100:
UniRef100_Q80XH7,
UniRef100_Q9WVF7
UniRef90:
UniRef90_Q9WVF7
UniRef50:
UniRef50_Q9WVF7
UniGene:
Mm.35061
CCDS:
CCDS19525.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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