| Type | Description |
|---|---|
| Definition | polymerase (DNA directed), beta |
| Date | Results | Publications |
|---|---|---|
| 2019-07-20 11:04:00 | DNA polymerases beta and lambda in single-nucleotide and multinucleotide pathways of mammalian base excision DNA repair | 30763888 |
| 2019-05-11 11:49:00 | The Polb/p53 double knockout animals exclusively developed medulloblastoma and no other type of brain tumor. | 30274781 |
| 2019-01-12 11:48:00 | To evaluate whether Polb might be causative in senescence induction, the study evaluated the impact of murine Polb nullizygosity on senescence. Unexposed DNA polymerase beta-null primary fibroblasts exhibit a robust increase in the number of senescent cells compared to wild-type (11-fold, P < 0.001), demonstrating that loss DNA polymerase betais sufficient to induce senescence. | 29968395 |
| 2017-12-30 12:36:00 | Mitochondria from pol beta-deficient mouse fibroblasts had compromised DNA repair and showed elevated levels of superoxide radicals after hydrogen peroxide treatment. Mitochondria in pol beta-deficient fibroblasts displayed altered morphology by electron microscopy. | 29100041 |
| 2017-10-07 11:13:00 | pol beta contains a specific NLS sequence in the N-terminal lyase domain that promotes transport of the protein independent of its interaction partners. Active nuclear uptake allows development of a nuclear/cytosolic concentration gradient against a background of passive diffusion. | 27956495 |
| Type | IDs |
|---|---|
| Synonymous | A430088C08Rik |
| Gene |
UniProtKB-ID:
DPOLB_MOUSE
UniprotKB:
Q8K409
UniParc:
UPI0000028A90
EMBL:
AK146745,
AK151436,
BC060998,
AK077127,
BC006681,
AF513911
Ensembl:
ENSMUSG00000031536
KO:
mmu:18970
|
| Nucleutide sequences |
EMBL-CDS:
BAE27405.1,
AAM49616.1,
AAH06681.1,
BAC36630.1,
BAE30399.1,
AAH60998.1
Ensembl_TRS:
ENSMUST00000033938
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000033938
RefSeq:
XP_036009721.1,
XP_036009722.1,
XP_011240428.1,
XP_006509093.1,
NP_035260.1,
XP_030099215.1
|
| Others |
UniRef100:
UniRef100_Q8K409
UniRef90:
UniRef90_Q8K409
UniRef50:
UniRef50_P06746
UniGene:
Mm.123211,
Mm.473777
CCDS:
CCDS22181.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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