| Type | Description |
|---|---|
| Definition | enoyl-CoA hydratase, short chain 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-31 13:17:00 | Novel ECHS1 mutations in Leigh syndrome identified by whole-exome sequencing in five Chinese families: case report. | 32677908 |
| 2020-10-24 14:02:00 | ECHS1 suppresses renal cell carcinoma development through inhibiting mTOR signaling activation. | 31891870 |
| 2020-06-20 11:34:00 | In clear cell renal cell carcinoma (ccRCC) ECHS1 downregulation induced fatty acid (FA) and branched-chain amino acid (BCAA) accumulation, which inhibited AMPK-promoted expression of GATA3, a transcriptional activator of ECHS1. BCAA accumulation induced activation of mTORC1 and de novo FA synthesis and promoted cell proliferation. GATA3 expression phenocopied ECHS1 in predicting ccRCC progression and patient survival. | 31690668 |
| 2018-07-14 11:24:00 | Due to enoyl coenzyme A hydratase, short chain, 1, mitochondria (ECHS1) deficiency. | 28409271 |
| 2017-12-30 12:46:00 | exceeding nutrients suppress Enoyl-CoA hydratase-1 (ECHS1) activity by inducing its acetylation resulting in accumulation of fatty acids and branched-chain amino acids and oncogenic mTOR activation | 28878358 |
| Type | IDs |
|---|---|
| Synonymous | ECHS1D, SCEH |
| Gene |
UniProtKB-ID:
ECHM_HUMAN
UniprotKB:
P30084
UniParc:
UPI000013CC49
EMBL:
X98129,
D13900,
BC008906,
X98126,
X98128,
BT007123,
X98127,
AL360181
Ensembl:
ENSG00000127884
KO:
hsa:1892
|
| Nucleutide sequences |
EMBL-CDS:
CAA66808.1,
BAA03001.1,
AAP35787.1,
AAH08906.1
Ensembl_TRS:
ENST00000368547
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000357535
RefSeq:
NP_004083.3
|
| Others |
UniRef100:
UniRef100_P30084
UniRef90:
UniRef90_P30084
UniRef50:
UniRef50_P30084
UniGene:
Hs.76394
CCDS:
CCDS7681.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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