| Type | Description |
|---|---|
| Definition | phospholamban |
| Date | Results | Publications |
|---|---|---|
| 2020-12-12 13:22:00 | The phospholamban p.(Arg14del) pathogenic variant leads to cardiomyopathy with heart failure and is unreponsive to standard heart failure therapy. | 32555305 |
| 2020-10-24 13:57:00 | HuR regulates phospholamban expression in isoproterenol-induced cardiac remodelling. | 31373621 |
| 2020-05-02 10:07:00 | the sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA2)-regulating protein phospholamban (PLN) is identified as a physiological SPPL2c substrate. | 30733280 |
| 2020-04-04 11:11:00 | Ablation of phospholamban rescues reperfusion arrhythmias but exacerbates myocardium infarction in hearts with Ca2+/calmodulin kinase II constitutive phosphorylation of ryanodine receptors. | 30169578 |
| 2019-12-21 11:09:00 | SERCA pumping efficiency (measured as an apparent coupling ratio: Ca(2+) uptake/ATP hydrolysis) was unaffected by PLN deficiency in skeletal muscle. Study lends support to the notion that PLN serves a functionally distinct role from that of sarcolipin in skeletal muscle physiology. | 30601702 |
| Type | IDs |
|---|---|
| Synonymous | Plb |
| Gene |
UniProtKB-ID:
PPLA_MOUSE
UniprotKB:
P61014
UniParc:
UPI0000003E51
EMBL:
S46792,
BC061097,
AK052199,
AK040718,
AK002622,
AK142708
Ensembl:
ENSMUSG00000038583
KO:
mmu:18821
|
| Nucleutide sequences |
EMBL-CDS:
BAB22237.1,
BAC34880.1,
BAE25168.1,
AAH61097.1,
AAB23706.1,
BAC30680.1
Ensembl_TRS:
ENSMUST00000218468,
ENSMUST00000219491,
ENSMUST00000163319,
ENSMUST00000220197,
ENSMUST00000219921,
ENSMUST00000046221
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000151745,
ENSMUSP00000151966,
ENSMUSP00000151641,
ENSMUSP00000132743,
ENSMUSP00000045709,
ENSMUSP00000151860
RefSeq:
NP_001135399.1,
NP_075618.1
|
| Others |
UniRef100:
UniRef100_P61014
UniRef90:
UniRef90_P61014
UniRef50:
UniRef50_P61014
UniGene:
Mm.34145
CCDS:
CCDS35899.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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