| Type | Description |
|---|---|
| Definition | phosphoinositide kinase, FYVE type zinc finger containing |
| Date | Results | Publications |
|---|---|---|
| 2020-02-29 10:52:00 | Study shows that PIKfyve modulation of lysosomal degradative activity and protein expression is essential to maintain lysosomal homeostasis in macrophages. | 31427458 |
| 2019-11-02 12:02:00 | PIKfyve inhibition leads to impaired degradative capacity, ion dysregulation, abated autophagic flux and a massive enlargement of lysosomes. | 29661845 |
| 2019-01-26 12:26:00 | enlarged vacuole formation in PIKfyve-deficient cells was not rescued by Ca2+ or over expression of TRPML1. It is likely that the acidification and vacuolation arrest is bifurcating downstream of PIKfyve | 30295876 |
| 2018-06-30 11:36:00 | these studies identify a novel role for PIKfyve in controlling the delivery of proteins from the endosomal compartment to the melanosome, a role that is distinct from the role of PIKfyve in the reformation of lysosomes from endolysosomes. | 29584722 |
| 2018-02-24 11:03:00 | The authors provide evidence that inactivation of PIKfyve by the selective inhibitor STA suppresses excessive mitochondrial reactive oxygen species production and apoptosis through a SIRT3-dependent pathway in cardiomyoblasts. | 28396567 |
| Type | IDs |
|---|---|
| Synonymous | 5230400C17Rik, Pip5k, Pip5k3, Pipk5k3, PipkIII, p235 |
| Gene |
UniProtKB-ID:
FYV1_MOUSE,
D3Z5N5_MOUSE
UniprotKB:
Q9Z1T6,
D3Z5N5
UniParc:
UPI000217CB2B,
UPI0000F4CD0C,
UPI00005B213F,
UPI0000E445E8
EMBL:
AK139116,
AC164079,
AK017186,
AF102777,
AK165350,
AK173077
Ensembl:
ENSMUSG00000025949
KO:
mmu:18711
|
| Nucleutide sequences |
EMBL-CDS:
BAB30626.3,
BAD32355.1,
BAE23894.1,
BAE38145.1,
AAD10191.1
Ensembl_TRS:
ENSMUST00000097707,
ENSMUST00000081154
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000095314,
ENSMUSP00000079926
RefSeq:
NP_035216.2,
XP_036018672.1,
XP_006495842.1,
XP_006495844.1,
XP_006495840.1,
XP_030108131.1,
XP_006495839.1,
XP_036018669.1,
NP_001297553.1,
XP_006495845.1,
XP_011236756.1,
XP_036018671.1,
XP_030108127.1
|
| Others |
UniRef100:
UniRef100_Q9Z1T6,
UniRef100_D3Z5N5
UniRef90:
UniRef90_Q9Y2I7,
UniRef90_Q9Z1T6
UniRef50:
UniRef50_Q9Y2I7
UniGene:
Mm.38370
CCDS:
CCDS78600.1,
CCDS35601.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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