| Type | Description |
|---|---|
| Definition | phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha |
| Date | Results | Publications |
|---|---|---|
| 2021-02-20 13:29:00 | Class II phosphatidylinositol 3-kinase alpha and beta isoforms are required for vascular smooth muscle Rho activation, contraction and blood pressure regulation in mice. | 32192434 |
| 2020-09-19 16:23:00 | Cbl-PI3K interaction regulates Cathepsin K secretion in osteoclasts. | 31299383 |
| 2020-04-18 11:46:00 | Pik3c2a regulates shear stress-associated autophagy and cell size regulation.PI3KC2alpha, required for ciliogenesis and primary cilium functions, promotes the synthesis of a local pool of phosphatidylinositol-3-phosphate upon shear stress. | 31941925 |
| 2020-02-01 13:08:00 | Both PI3K-C2alpha and PI3K-C2beta are required for normal uterine smooth muscle contraction and parturition mainly through their involvement in Rhoa activation. | 30476019 |
| 2019-07-13 10:54:00 | Studies indicate that the structural changes in PI3KC2alpha-deficient platelets are limited to the membrane, occur without major changes in lipid composition, and selectively impair cell function during thrombus formation. Functionally, PI3KC2alpha-deficient platelets exhibit impaired thrombosis specifically under conditions involving membrane tethering. | 30421419 |
| Type | IDs |
|---|---|
| Synonymous | Cpk-m, PI3KC2 |
| Gene |
UniProtKB-ID:
P3C2A_MOUSE,
F8VPL2_MOUSE
UniprotKB:
Q61194,
F8VPL2
UniParc:
UPI000058E3EC,
UPI000058E4F0,
UPI00001F502F
EMBL:
AC104918,
U55772,
U52193,
AK049609,
AC163222
Ensembl:
ENSMUSG00000030660
KO:
mmu:18704
|
| Nucleutide sequences |
EMBL-CDS:
AAB07682.1,
AAC52604.1
Ensembl_TRS:
ENSMUST00000170430,
ENSMUST00000206219
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000126092,
ENSMUSP00000146181
RefSeq:
NP_035213.2,
XP_030098074.1,
XP_006507504.1,
XP_006507503.1
|
| Others |
UniRef100:
UniRef100_Q61194,
UniRef100_F8VPL2
UniRef90:
UniRef90_Q61194
UniRef50:
UniRef50_O00443
UniGene:
Mm.3810
CCDS:
CCDS52371.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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