| Type | Description |
|---|---|
| Definition | PHD finger protein 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-04-25 12:26:00 | PHF2 depletion induces R-loop accumulation that leads to extensive DNA damage and cell cycle arrest. These data reveal a role of PHF2 as a guarantor of genome stability that allows proper expansion of neural progenitors during development. | 31488723 |
| 2018-12-22 11:09:00 | The paper's findings establish a downstream epigenetic checkpoint, whereby Phf2, through facilitating H3K9me2 demethylation at specific gene promoters, protects liver from the pathogenesis progression of Non-alcoholic Fatty Liver Disease. | 29844386 |
| 2015-07-25 11:14:00 | these results demonstrate that PHF2 histone demethylase controls adipogenic gene expression during differentiation. | 25266703 |
| 2015-06-20 11:22:00 | PHF2 enhances osteoblast differentiation by demethylating Runx2, while suppressor of variegation 3-9 homolog 1 (SUV39H1) inhibits bone formation by methylating it. | 25257467 |
| 2014-10-11 12:52:00 | Arid5b recruits Phf2 to the promoter region of Sox9 target genes and stimulates H3K9me2 demethylation of these genes. | 24276541 |
| Type | IDs |
|---|---|
| Synonymous | GRC5 |
| Gene |
UniProtKB-ID:
PHF2_MOUSE
UniprotKB:
Q9WTU0
UniParc:
UPI0000191082
EMBL:
AK172995,
AF043726,
AC109249,
BC051633
Ensembl:
ENSMUSG00000038025
KO:
mmu:18676
|
| Nucleutide sequences |
EMBL-CDS:
AAD21792.1,
AAH51633.1,
BAD32273.1
Ensembl_TRS:
ENSMUST00000035540
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000047308
RefSeq:
NP_035208.2
|
| Others |
UniRef100:
UniRef100_Q9WTU0
UniRef90:
UniRef90_Q9WTU0
UniRef50:
UniRef50_Q9WTU0
UniGene:
Mm.486213
CCDS:
CCDS26496.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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