| Type | Description |
|---|---|
| Definition | perforin 1 (pore forming protein) |
| Date | Results | Publications |
|---|---|---|
| 2021-03-27 14:40:00 | Impaired Function in Mice Lacking Perforin-2. | 32180773 |
| 2021-03-20 13:31:00 | Perforin Acts as an Immune Regulator to Prevent the Progression of NAFLD. | 32528465 |
| 2020-12-12 13:24:00 | Loss of NKG2D in murine NK cells leads to increased perforin production upon long-term stimulation with IL-2. | 32052406 |
| 2020-02-22 11:25:00 | CD8 T cell-derived perforin is detrimental to spinal cord injury recovery in the mouse model. Mechanistically, this effect occurs because perforin increases blood-spinal cord barrier permeability, causing inflammatory cells and related cytokines to infiltrate and disrupt the nervous system. | 30894275 |
| 2019-09-14 10:43:00 | Mutant perforin displayed markedly enhanced thermal stability and lytic function, despite its trafficking from the endoplasmic reticulum remaining unchanged. | 29416110 |
| Type | IDs |
|---|---|
| Synonymous | Pfn, Pfp, Prf-1 |
| Gene |
UniProtKB-ID:
PERF_MOUSE,
A2RSY7_MOUSE
UniprotKB:
P10820,
A2RSY7
UniParc:
UPI000002797F
EMBL:
J04148,
X12760,
BC137962,
X51340,
X51446,
BC132300,
M23182,
M95527,
X60165
Ensembl:
ENSMUSG00000037202
KO:
mmu:18646
|
| Nucleutide sequences |
EMBL-CDS:
CAA35721.1,
CAA42731.1,
AAA39909.1,
CAA31251.1,
AAA39910.1,
AAB01574.1,
AAI37963.1,
AAI32301.1
Ensembl_TRS:
ENSMUST00000035419,
ENSMUST00000219375
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000041483,
ENSMUSP00000151354
RefSeq:
NP_035203.3,
XP_006513433.1
|
| Others |
UniRef100:
UniRef100_P10820
UniRef90:
UniRef90_P10820
UniRef50:
UniRef50_P14222
UniGene:
Mm.240313
CCDS:
CCDS23875.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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