| Type | Description |
|---|---|
| Definition | pyruvate dehydrogenase E1 alpha 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-06 13:58:00 | Conditional knockout of pyruvate dehydrogenase in mouse pancreatic betacells causes morphological and functional changes. | 32319629 |
| 2020-10-31 13:20:00 | Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis. | 33022274 |
| 2020-08-01 14:17:00 | Silencing Sik2 further diminished SIRT3 activity and enhanced acetylation of PDHA1 K83 level. Reconstruction of SIRT3 restored PDH activity and thermogenic markers expression in differentiated brown adipocytes from SIRT3 knockout (KO) mice | 31409767 |
| 2019-08-31 13:35:00 | exercise capacity during high-intensity exercise was severely impaired in PDHmKO mice, in parallel with a large increase in plasma lactate concentration. | 30153068 |
| 2019-05-18 10:28:00 | Both mitochondrial and nuclear Pyruvate dehydrogenase complex sustain prostate tumorigenesis by controlling lipid biosynthesis, thus suggesting this complex as a potential target for cancer therapy. | 29335542 |
| Type | IDs |
|---|---|
| Synonymous | Pdha-1 |
| Gene |
UniProtKB-ID:
ODPA_MOUSE,
Q3UFJ3_MOUSE
UniprotKB:
P35486,
Q3UFJ3
UniParc:
UPI00000018B6
EMBL:
AK169289,
M76727,
BC007142,
AK148459,
AK167987,
AK145718,
AK168152
Ensembl:
ENSMUSG00000031299
KO:
mmu:18597
|
| Nucleutide sequences |
EMBL-CDS:
AAA53046.1,
AAH07142.1,
BAE39978.1,
BAE26608.1,
BAE28567.1,
BAE41046.1,
BAE40117.1
Ensembl_TRS:
ENSMUST00000033662
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000033662
RefSeq:
NP_032836.1
|
| Others |
UniRef100:
UniRef100_P35486
UniRef90:
UniRef90_P35486
UniRef50:
UniRef50_P35486
UniGene:
Mm.34775
CCDS:
CCDS41195.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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