| Type | Description |
|---|---|
| Definition | phosphodiesterase 8A |
| Date | Results | Publications |
|---|---|---|
| 2018-06-16 10:11:00 | our studies demonstrate that PDE8A inhibition by enzymatic inhibitors or PDE8A-Raf-1 kinase complex disruptors decreases Teff cell adhesion and migration under flow, and represents a novel approach to target T cells in inflammation | 28851628 |
| 2012-05-12 11:11:00 | findings suggest that both PDE8A and PDE8B play essential roles to maintain low cAMP levels, thereby suppressing resting steroidogenesis by keeping CEH/HSL inactive and StAR protein expression low | 22232524 |
| 2010-11-06 10:16:00 | PDE8 as a novel target for suppression of Teff cell functions, including adhesion to endothelial cells | 20711499 |
| 2010-09-13 11:24:00 | PDE8A plays a critical role in the modulation of at least one compartment of cAMP and hence activity during beta-adrenergic receptor (betaAR) activation in ventricular myocytes. | 20353794 |
| 2010-01-21 00:00:00 | pharmacological manipulation of PDE8A, alone or in combination with other PDEs present in Leydig cells, may be exploited to modulate testosterone synthesis | 17172443 |
| Type | IDs |
|---|---|
| Synonymous | AI551852, Pde8 |
| Gene |
UniProtKB-ID:
PDE8A_MOUSE
UniprotKB:
O88502
UniParc:
UPI00000298D0
EMBL:
AF067806,
BC132145,
BC125578
Ensembl:
ENSMUSG00000025584
KO:
mmu:18584
|
| Nucleutide sequences |
EMBL-CDS:
AAC40194.1,
AAI32146.1,
AAI25579.1
Ensembl_TRS:
ENSMUST00000026672
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000026672
RefSeq:
NP_032829.1,
XP_036008663.1
|
| Others |
UniRef100:
UniRef100_O88502
UniRef90:
UniRef90_O88502
UniRef50:
UniRef50_O88502
UniGene:
Mm.371577
CCDS:
CCDS40005.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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